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https://hdl.handle.net/1822/59229
Título: | Biodegradable poly(L-lactic acid) scaffolds with internal hyaluronic acid coating. biological response in vitro |
Autor(es): | Antunes, J. Costa Soria, J.M. Mano, J. F. Gómez Ribelles, J. L. |
Data: | 2008 |
Editora: | Mary Ann Liebert Inc. |
Revista: | Tissue Engineering. Part A |
Citação: | Antunes, J. C., Soria, J. M., et. al. (2008, May). Biodegradable poly (L-lactic acid) scaffolds with internal hyaluronic acid coating. biological response in vitro. In TISSUE ENGINEERING PART A (Vol. 14, No. 5, pp. 814-814). 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA: MARY ANN LIEBERT INC. |
Resumo(s): | [Excerpt] Poly(L-lactic acid), a synthetic biodegradable polyester, is widely accepted for many tissue engineering applications. Hyaluronic acid (HA), as a polysaccharide of the extra cellular matrix (ECM), besides exhibiting an excellent biocompatibility, influences cell signaling, growth and differentiation. A combination between these materials might be interesting for tissue engineering studies. However, HA must be chemically modified for this use because of its easy dissolution in water and quick degradation in biological environments. Glutaraldehyde, GA, has been proposed as crosslinking agent to produce HA hydrogels. However, accordingly to the literature, there are contradictory results about the experimental protocol to be used, and relating to the cytotoxicity caused by glutaraldehyde remaining in the sample after crosslinking reactions. [...] |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/59229 |
ISSN: | 1937-3341 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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TermisEU_P48.pdf | 32,7 kB | Adobe PDF | Ver/Abrir |