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https://hdl.handle.net/1822/60042
Título: | Remote activation of activin a type ii receptor via magnetic nanoparticles for tendon regeneration strategies |
Autor(es): | Gonçalves, A I Rotherham, M. Markides, H. Rodrigues, Márcia T. Reis, R. L. Gomes, Manuela E. Haj, A. E. |
Palavras-chave: | Activin receptor type IIA TGF-β/Smad2/3 signaling pathway |
Data: | Abr-2018 |
Editora: | The British Editorial Society of Bone & Joint Surgery |
Citação: | Gonçalves A. I., Rotherham M., Markides H., Rodrigues M. T., Reis R. L., Gomes M. E., Haj A. E. Remote activation of activin a type ii receptor via magnetic nanoparticles for tendon regeneration strategies, Orthopaedic Proceedings, Vol. 100-B, Issue S4, doi:10.1302/1358-992X.2018.4.072, 2018 |
Resumo(s): | Tendon injuries are a worldwide problem affecting several age groups and stem cell based therapies hold potential for tendon strategies guiding tendon regeneration. Tendons rely on mechano-sensing mechanisms that regulate homeostasis and influence regeneration. The mechanosensitive receptors available in cell membranes sense the external stimuli and initiate mechanotransduction processes. Activins are members of the TGF-β superfamily which participate in several tendon biological processes. It is envisioned that the activation of the activin receptor, trigger downstream Smad2/3 pathway thus regulating the transcription of tenogenic genes driving stem cell differentiation. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/60042 |
DOI: | 10.1302/1358-992X.2018.4.072 |
ISSN: | 2049-4416 |
Versão da editora: | https://online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.2018.4.072 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19616-EORS'17_AIGoncalves.pdf | 118,11 kB | Adobe PDF | Ver/Abrir |