Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/60748
Título: | New nitrogen compounds coupled to phenolic units with antioxidant and antifungal activities: Synthesis and structure–activity relationship |
Autor(es): | Bettencourt, Ana Paula Castro, Marián Silva, João Fernandes, Francisco Coutinho, O. P. Sousa, Maria João Proença, M. Fernanda R. P. Areias, Filipe |
Palavras-chave: | Imidazoles phenolic compounds antifungal activity MIC antioxidant capacity structure-activity relationship |
Data: | 3-Out-2018 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Molecules |
Resumo(s): | A selection of 1-amino-2-arylidenamine-1,2-(dicyano)ethenes <b>3</b> was synthesized and cyclized to 2-aryl-4,5-dicyano-1<i>H</i>-imidazoles <b>4</b> upon reflux in ethyl acetate/acetonitrile, in the presence of manganese dioxide. These compounds were tested for their antioxidant capacity by cyclic voltammetry, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and deoxyribose degradation assays. The minimum inhibitory concentration of all compounds was evaluated against two yeast species, <i>Saccharomyces cerevisiae</i> and <i>Candida albicans</i>. Their toxicity was tested in mammal fibroblasts. Among the synthesised compounds, two presented dual antioxidant/antifungal activity without toxic effects in fibroblasts. The new compounds synthesized in this work are potential biochemical tools and/or therapeutic drugs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/60748 |
DOI: | 10.3390/molecules23102530 |
ISSN: | 1420-3049 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
molecules-23-02530.pdf | 571,67 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons