Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/60845

TítuloHydrogel-based magnetoelectric microenvironments for tissue stimulation
Autor(es)Hermenegildo, B.
Ribeiro, Clarisse
Pérez-Álvarez, L.
Vilas, José L.
Learmonth, David A.
Sousa, Rui A.
Martins, P.
Lanceros-Méndez, S.
Palavras-chavehydrogel
spheres
poly(vinylidene fluoride)
magnetoelectric
tissue engineering
DataSet-2019
EditoraElsevier
RevistaColloids and Surfaces B: Biointerfaces
CitaçãoHermenegildo, B.; Ribeiro, Clarisse; Pérez-Álvarez, L.; Vilas, José L.; Learmonth, David A.; Sousa, Rui A.; Martins, P.; Lanceros-Méndez, S., Hydrogel-based magnetoelectric microenvironments for tissue stimulation. Colloids and Surfaces B- Biointerfaces, 181, 1041-1047, 2019
Resumo(s)The development of strategies to mimic the natural environment of tissues with engineered scaffolds remains one of the biggest challenges of tissue engineering. Hydrogels appear as suitable materials for this purpose due to their substantial water content, biocompatibility, and for being able to carry nanomaterials that introduce new functionalities to the hydrogel. The incorporation of magnetically responsive and, in particular, magnetoelectric materials into the hydrogel-based scaffolds are a promising approach for bone tissue engineering applications once it can promote not only tissue regeneration through magnetic to mechanic to electrical conversion/stimuli but also the external control of the scaffold by the application of magnetic fields. This work reports on a new CoFe2O4/ Methacrylated Gellan Gum (GGMA)/poly(vinylidene fluoride) (PVDF) hydrogel-based scaffold with 20kPa Young's modulus and cell viability superior to 80%. The 1µm thick PVDF/CoFe2O4 spheres added to GGMA gel (2wt.%) exhibit 20emu.g-1 magnetization saturation, 2.7kOe magnetic coercivity and -phase contents 78%, leading to a piezoelectric response |d33| of 22 pC N-1 and a magnetoelectric response of |d33| 6 pC N-1 at a DC magnetic field of 220mT, as verified for the CoFe2O4/PVDF spheres with 20wt.% filler content. Such characteristics allow novel tissue regeneration strategies approaches once CoFe2O4/GGMA/PVDF has a porous 3-D structure, biocompatibility, bioresorbability, and mechanical/electrical dynamic responses that can be triggered by an applied external magnetic field.
TipoArtigo
URIhttps://hdl.handle.net/1822/60845
DOI10.1016/j.colsurfb.2019.06.023
ISSN0927-7765
e-ISSN0927-7765
Versão da editorahttp://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/
Arbitragem científicayes
AcessoAcesso restrito UMinho
Aparece nas coleções:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
FUNCTIONAL AND SMART MATERIALS AND SURFACES FOR ADVANCED APPLICATIONS (2018 - ...)

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