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https://hdl.handle.net/1822/61456| Título: | Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis |
| Autor(es): | Carvalho, Agostinho Pasqualotto, A. C. Pitzurra, L. Romani, L Denning, D. W. Rodrigues, Fernando José dos Santos |
| Palavras-chave: | Aged Aspergillosis Aspergillosis, Allergic Bronchopulmonary Aspergillus fumigatus Case-Control Studies Cohort Studies Female Humans Lung Diseases, Fungal Male Middle Aged Polymorphism, Single Nucleotide Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptor 9 |
| Data: | 15-Fev-2008 |
| Editora: | Oxford University Press |
| Revista: | Journal of Infectious Diseases |
| Resumo(s): | Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/61456 |
| DOI: | 10.1086/526500 |
| ISSN: | 0022-1899 |
| e-ISSN: | 1537-6613 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| carvalho2008.pdf | 91,19 kB | Adobe PDF | Ver/Abrir |
