Please use this identifier to cite or link to this item:

Full metadata record
DC FieldValueLanguage
dc.contributor.authorMuzny, Christina A.por
dc.contributor.authorTaylor, Christopher M.por
dc.contributor.authorSwords, W. Edwardpor
dc.contributor.authorTamhane, Ashutoshpor
dc.contributor.authorChattopadhyay, Debasishpor
dc.contributor.authorCerca, Nunopor
dc.contributor.authorSchwebke, Jane R.por
dc.identifier.citationMuzny, Christina A.; Taylor, Christopher M.; Swords, W. Edward; Tamhane, Ashutosh; Chattopadhyay, Debasish; Cerca, Nuno; Schwebke, Jane R., An updated conceptual model on the pathogenesis of bacterial vaginosis. Journal of Infectious Diseases, 220(9), 1399-1405, 2019por
dc.description.abstractBacterial vaginosis (BV) is the most common cause of vaginal discharge. It is associated with an increased risk of preterm delivery, pelvic inflammatory disease, and an increased risk of acquisition of sexually transmitted infections including human immunodeficiency virus (HIV). The epidemiology of BV supports sexual transmission. However, its etiology remains unknown. At the center of the debate is whether BV is caused by a primary pathogen or a polymicrobial consortium of microorganisms that are sexually transmitted. We previously published a conceptual model hypothesizing that BV is initiated by sexual transmission of Gardnerella vaginalis. Critics of this model have iterated that G. vaginalis is found in virginal women and in sexually active women with a normal vaginal microbiota. In addition, colonization does not always lead to BV. However, recent advances in BV pathogenesis research have determined the existence of 13 different species within the genus Gardnerella. It may be that healthy women are colonized by nonpathogenic Gardnerella species, whereas virulent strains are involved in BV development. Based on our results from a recent prospective study, in addition to an extensive literature review, we present an updated conceptual model for the pathogenesis of BV that centers on the roles of virulent strains of G. vaginalis, as well as Prevotella bivia and Atopobium vaginae.por
dc.description.sponsorshipThis work was supported by the National Institute of Allergy and Infectious Diseases (grant K23AI106957 to C. A. M.).por
dc.publisherUniversity of Chicago Presspor
dc.subjectBacterial vaginosispor
dc.subjectGardnerella vaginalispor
dc.subjectPrevotella biviapor
dc.subjectAtopobium vaginaepor
dc.titleAn updated conceptual model on the pathogenesis of bacterial vaginosispor
dc.subject.wosScience & Technologypor
sdum.journalJournal of Infectious Diseasespor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
  Restricted access
355,37 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID