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https://hdl.handle.net/1822/62004| Título: | New biomarkers defining a novel early stage of Fabry nephropathy: A diagnostic test study |
| Autor(es): | Aguiar, Patrício Azevedo, Olga Pinto, Rui Marino, Jacira Baker, Robert Cardoso, Carlos Ducla Soares, José Luís Hughes, Derralynn |
| Palavras-chave: | Adult Aged Albuminuria Biomarkers Collagen Type IV Cross-Sectional Studies Disease Progression Early Diagnosis Fabry Disease Female Humans Kidney Male Middle Aged Prospective Studies Renal Insufficiency, Chronic Young Adult beta-N-Acetyl-Galactosaminidase Fabry disease nephropathy N-acetyl-beta-glucosaminidase N-acetyl-β-glucosaminidase |
| Data: | Jun-2017 |
| Editora: | Elsevier |
| Revista: | Molecular Genetics and Metabolism |
| Citação: | Aguiar, P., Azevedo, O., Pinto, R., Marino, et. al.(2017). New biomarkers defining a novel early stage of Fabry nephropathy: a diagnostic test study. Molecular genetics and metabolism, 121(2), 162-169. |
| Resumo(s): | Renal involvement in Fabry disease is a major determinant of overall disease prognosis and early enzyme replacement therapy seems effective in preventing progression of kidney injury. Gb3 storage, glomerular sclerosis and tubulo-interstitial fibrosis may occur with minimal or no changes on standard renal tests, hence alternative markers of renal dysfunction are crucial. In this study we compared several biomarkers with albuminuria in the identification of incipient Fabry nephropathy and their diagnostic accuracy to identify chronic kidney disease (CKD) stage≥2. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/62004 |
| DOI: | 10.1016/j.ymgme.2017.05.007 |
| ISSN: | 1096-7192 |
| e-ISSN: | 1096-7206 |
| Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1096719217302251 |
| Arbitragem científica: | yes |
| Acesso: | Acesso restrito autor |
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Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| aguiar2017.pdf Acesso restrito! | 715,34 kB | Adobe PDF | Ver/Abrir |
