Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62062
Título: | Macro- and micro-structural white matter differences correlate with cognitive performance in healthy aging |
Autor(es): | Marques, Paulo César Gonçalves Soares, José Miguel Montenegro Magalhães, Ricardo José Silva Santos, Nadine Correia Sousa, Nuno |
Palavras-chave: | Aged Aged, 80 and over Aging Brain Cluster Analysis Diffusion Tensor Imaging Female Humans Magnetic Resonance Imaging Male Middle Aged Organ Size Principal Component Analysis Psychological Tests White Matter Cognition Cognitive performance Tract-based spatial statistics |
Data: | Mar-2016 |
Editora: | Springer |
Revista: | Brain Imaging and Behavior |
Citação: | Marques, P. C. G., Soares, J. M. M., da Silva Magalhães, R. J., Santos, N. C., & Sousa, N. J. C. (2016). Macro-and micro-structural white matter differences correlate with cognitive performance in healthy aging. Brain imaging and behavior, 10(1), 168-181. |
Resumo(s): | Studies have shown that white matter (WM) volumetric reductions and overall degradation occur with aging. Nonetheless little is known about the WM alterations that may underlie different cognitive status in older individuals. The main goal of the present work was to identify and characterize possible macro and microstructural WM alterations that could distinguish between older healthy individuals with contrasting cognitive profiles (i.e., "poor" vs "good" cognitive performers). Structural and diffusion magnetic resonance imaging was performed in order to quantify local WM volumes, white matter signal abnormalities (WMSA) volume (a measure of lesion burden) and diffusion tensor imaging scalar maps known to probe WM microstructure. A battery of neurocognitive/psychological tests was administered to assess the cognitive performance. Poor performers showed a higher slope for the positive association between WMSA volume and age compared to good performers. Even when controlling for WMSA volume, poor performers also evidenced lower fractional anisotropy, as well as positive associations with age with higher slopes of regression parameters in radial and axial diffusivity. Altogether results suggest that cognitive performance is related to differences in WM, with poor cognitive performers displaying signs of faster aging in WM. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62062 |
DOI: | 10.1007/s11682-015-9378-4 |
ISSN: | 1931-7557 |
e-ISSN: | 1931-7565 |
Versão da editora: | https://link.springer.com/article/10.1007/s11682-015-9378-4 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Marques-2015-Macro--and-micro-structural-white-m.pdf Acesso restrito! | 11,38 MB | Adobe PDF | Ver/Abrir |