Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/62062

TítuloMacro- and micro-structural white matter differences correlate with cognitive performance in healthy aging
Autor(es)Marques, Paulo César Gonçalves
Soares, José Miguel Montenegro
Magalhães, Ricardo José Silva
Santos, Nadine Correia
Sousa, Nuno
Palavras-chaveAged
Aged, 80 and over
Aging
Brain
Cluster Analysis
Diffusion Tensor Imaging
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Principal Component Analysis
Psychological Tests
White Matter
Cognition
Cognitive performance
Tract-based spatial statistics
DataMar-2016
EditoraSpringer
RevistaBrain Imaging and Behavior
CitaçãoMarques, P. C. G., Soares, J. M. M., da Silva Magalhães, R. J., Santos, N. C., & Sousa, N. J. C. (2016). Macro-and micro-structural white matter differences correlate with cognitive performance in healthy aging. Brain imaging and behavior, 10(1), 168-181.
Resumo(s)Studies have shown that white matter (WM) volumetric reductions and overall degradation occur with aging. Nonetheless little is known about the WM alterations that may underlie different cognitive status in older individuals. The main goal of the present work was to identify and characterize possible macro and microstructural WM alterations that could distinguish between older healthy individuals with contrasting cognitive profiles (i.e., "poor" vs "good" cognitive performers). Structural and diffusion magnetic resonance imaging was performed in order to quantify local WM volumes, white matter signal abnormalities (WMSA) volume (a measure of lesion burden) and diffusion tensor imaging scalar maps known to probe WM microstructure. A battery of neurocognitive/psychological tests was administered to assess the cognitive performance. Poor performers showed a higher slope for the positive association between WMSA volume and age compared to good performers. Even when controlling for WMSA volume, poor performers also evidenced lower fractional anisotropy, as well as positive associations with age with higher slopes of regression parameters in radial and axial diffusivity. Altogether results suggest that cognitive performance is related to differences in WM, with poor cognitive performers displaying signs of faster aging in WM.
TipoArtigo
URIhttps://hdl.handle.net/1822/62062
DOI10.1007/s11682-015-9378-4
ISSN1931-7557
e-ISSN1931-7565
Versão da editorahttps://link.springer.com/article/10.1007/s11682-015-9378-4
Arbitragem científicayes
AcessoAcesso restrito UMinho
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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