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TitleCrystallin fusion proteins improve the thermal properties of hair
Author(s)Tinoco, Ana
Gonçalves, J. A.
Silva, Carla
Cavaco-Paulo, Artur
Ribeiro, Artur
gamma D-crystallin
thermal damage
keratin-based peptide
Issue date25-Oct-2019
PublisherFrontiers Media S.A.
JournalFrontiers in Bioengineering and Biotechnology
CitationTinoco, Ana; Gonçalves, J. A.; Silva, Carla; Cavaco-Paulo, Artur; Ribeiro, Artur, Crystallin fusion proteins improve the thermal properties of hair. Frontiers in Bioengineering and Biotechnology, 7(298), 2019
Abstract(s)Styling hair with straightening irons is a popular daily hair routine that significantly damage the hair keratin fiber due to the high temperature applied. In this study, we investigate the effect of two fusion proteins based on the human eye D-crystallin conjugated with a keratin-based peptide (KP-Cryst Wt and KP-Cryst Mut) on hair exposed to thermal damage. The mutant form was designed to improve protein stability and promote interaction with the hair. Through the study, it was demonstrated the protection of Asian and Caucasian virgin hair's structure by the pretreatments with the KP-Cryst fusion proteins. After hair thermal exposure, a higher water content was quantified by TGA on the hair fibers pretreated with the fusion proteins (about 38% for the KP-Cryst Wt and 44% for the KP-Cryst Mut). Also, negligible alterations in hair fibers' stiffness were observed after iron application, demonstrating the proteins capacity to effectively prevent the conversion of keratin -helix structure into -sheets. The results proved the capacity of the fusion proteins to bind to hair and protect it against high temperatures', supporting the development of new formulations based on the KP-Cryst proteins.
DescriptionThe Supplementary Material for this article can be found online at: 2019.00298/full#supplementary-material
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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