Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/62195

TitleHormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome
Author(s)Costa, Inês Campos
Carvalho, Hugo Nogueira
Figueiredo, Luís Pacheco
Tomada, Inês
Tomada, Nuno
Issue date2013
PublisherHindawi Publishing Corporation
JournalInternational Journal of Endocrinology
CitationCosta, I. C., Carvalho, H. N., Pacheco-Figueiredo, L., Tomada, I., & Tomada, N. (2013). Hormonal modulation in aging patients with erectile dysfunction and metabolic syndrome. International journal of endocrinology, 2013.
Abstract(s)Erectile dysfunction (ED), metabolic syndrome (MetS), and hypogonadism are closely related, often coexisting in the aging male. Obesity was shown to raise the risk of ED and hypogonadism, as well as other endocrinological disturbances with impact on erectile function. We selected 179 patients referred for ED to our andrology unit, aiming to evaluate gonadotropins and estradiol interplay in context of ED, MetS, and hypogonadism. Patients were stratified into groups in accordance with the presence (or not) of MetS and/or hypogonadism. Noticeable differences in total testosterone (TT) and free testosterone (FT) levels were found between patients with and without MetS. Men with MetS evidenced lower TT circulating levels with an increasing number of MetS parameters, for which hypertriglyceridemia and waist circumference strongly contributed. Regarding the hypothalamic-pituitary-gonadal axis, patients with hypogonadism did not exhibit raised LH levels. Interestingly, among those with higher LH levels, estradiol values were also increased. Possible explanations for this unexpected profile of estradiol may be the age-related adiposity, other estrogen-raising pathways, or even unknown mechanisms. Estradiol is possibly a molecule with further interactions beyond the currently described. Our results further enlighten this still unclear multidisciplinary and complex subject, raising new investigational opportunities
TypeArticle
URIhttps://hdl.handle.net/1822/62195
DOI10.1155/2013/107869
ISSN1687-8337
e-ISSN1687-8345
Publisher versionhttps://www.hindawi.com/journals/ije/2013/107869/abs/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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