Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62267
Título: | Hydrogel-based strategies to advance therapies for chronic skin wounds |
Autor(es): | da Silva, L. P. Reis, R. L. Correlo, V. M. Marques, A. P. |
Palavras-chave: | Chronic wounds Hydrogel Skin Tissue engineering Wound healing |
Data: | Mar-2019 |
Editora: | Annual Reviews |
Revista: | Annual Review of Biomedical Engineering |
Citação: | da Silva L. P., Reis R. L., Correlo V. M., Marques A. P. Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds, Annual Review of Biomedical Engineering, Vol. 21, pp. 145–69, doi:10.1146/annurev-bioeng-060418-052422, 2019 |
Resumo(s): | Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies.The intrinsic characteristics of hydrogels allow them to benefit cutaneous healing essentially by supporting a moist environment. This property has long been explored in wound management to aid in autolytic debridement. However, chronic wounds require additional therapeutic features that can be provided by a combination of hydrogels with biochemical mediators or cells, promoting faster and better healing.We survey hydrogel-based approaches with potential to improve the healing of chronic wounds by reviewing their effects as observed in preclinical models. Topics covered include strategies to ablate infection and resolve inflammation, the delivery of bioactive agents to accelerate healing, and tissue engineering approaches for skin regeneration. The article concludes by considering the relevance of treating chronic skin wounds using hydrogel-based strategies. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/62267 |
DOI: | 10.1146/annurev-bioeng-060418-052422 |
ISSN: | 1523-9829 |
e-ISSN: | 1545-4274 |
Versão da editora: | https://www.annualreviews.org/doi/full/10.1146/annurev-bioeng-060418-052422 |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19952-22_2019_LS.pdf Acesso restrito! | 3,95 MB | Adobe PDF | Ver/Abrir |