Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/62386

TítuloProinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline
Autor(es)Taipa, Ricardo
das Neves, Sofia P.
Sousa, Ana L.
Fernandes, Joana
Pinto, Claudia
Correia, Ana P.
Santos, Ernestina
Pinto, Pedro S.
Carneiro, Paula
Costa, Patrício Soares
Santos, Diana
Alonso, Isabel
Palha, Joana Almeida
Marques, Fernanda
Cavaco, Sara
Sousa, Nuno
Palavras-chaveNeuroinflammation
Alzheimer's disease
Cytokines
Disease progression
Cognition
Cerebrospinal fluid
Data2019
EditoraElsevier
RevistaNeurobiology of Aging
CitaçãoTaipa, R., das Neves, S. P., Sousa, A. L., et. al. (2019). Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline. Neurobiology of aging, 76, 125-132.
Resumo(s)Cumulative data suggest that neuroinflammation plays a prominent role in Alzheimer's disease (AD) pathogenesis. The purpose of this work was to assess if patients with AD present a specific cerebrospinal fluid (CSF) cytokine profile and if it correlates to disease progression. We determined the levels of 27 cytokines in CSF of patients with AD and compared them with patients with frontotemporal dementia and nondemented controls. In addition, we correlated the cytokine levels with cognitive status and disease progression after 12 months. Patients with AD had higher levels of proinflammatory and anti-inflammatory cytokines (eotaxin, interleukin [IL]-1ra, IL-4, IL-7, IL-8, IL-9, IL-10, IL-15, granulocyte colony-stimulating factor, monocyte chemotactic protein 1, platelet-derived growth factor, tumor necrosis factor alfa) compared to nondemented controls. There was a negative correlation between the disease progression and the levels of several cytokines (IL-1β, IL-4, IL-6, IL-9, IL-17A, basic fibroblast growth factor, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interferon gamma, macrophage inflammatory proteins-1β). To the best of our knowledge, this is the first study reporting a "protective" role of the upregulation of specific intrathecal cytokine levels in AD. This finding supports that a fine "rebalancing" of the immune system represents a new target in AD therapeutic approach.
TipoArtigo
URIhttps://hdl.handle.net/1822/62386
DOI10.1016/j.neurobiolaging.2018.12.019
ISSN0197-4580
e-ISSN1558-1497
Versão da editorahttps://www.sciencedirect.com/science/article/pii/S0197458019300090
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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