Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62386
Título: | Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline |
Autor(es): | Taipa, Ricardo das Neves, Sofia P. Sousa, Ana L. Fernandes, Joana Pinto, Claudia Correia, Ana P. Santos, Ernestina Pinto, Pedro S. Carneiro, Paula Costa, Patrício Soares Santos, Diana Alonso, Isabel Palha, Joana Almeida Marques, Fernanda Cavaco, Sara Sousa, Nuno |
Palavras-chave: | Neuroinflammation Alzheimer's disease Cytokines Disease progression Cognition Cerebrospinal fluid |
Data: | 2019 |
Editora: | Elsevier |
Revista: | Neurobiology of Aging |
Citação: | Taipa, R., das Neves, S. P., Sousa, A. L., et. al. (2019). Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline. Neurobiology of aging, 76, 125-132. |
Resumo(s): | Cumulative data suggest that neuroinflammation plays a prominent role in Alzheimer's disease (AD) pathogenesis. The purpose of this work was to assess if patients with AD present a specific cerebrospinal fluid (CSF) cytokine profile and if it correlates to disease progression. We determined the levels of 27 cytokines in CSF of patients with AD and compared them with patients with frontotemporal dementia and nondemented controls. In addition, we correlated the cytokine levels with cognitive status and disease progression after 12 months. Patients with AD had higher levels of proinflammatory and anti-inflammatory cytokines (eotaxin, interleukin [IL]-1ra, IL-4, IL-7, IL-8, IL-9, IL-10, IL-15, granulocyte colony-stimulating factor, monocyte chemotactic protein 1, platelet-derived growth factor, tumor necrosis factor alfa) compared to nondemented controls. There was a negative correlation between the disease progression and the levels of several cytokines (IL-1β, IL-4, IL-6, IL-9, IL-17A, basic fibroblast growth factor, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interferon gamma, macrophage inflammatory proteins-1β). To the best of our knowledge, this is the first study reporting a "protective" role of the upregulation of specific intrathecal cytokine levels in AD. This finding supports that a fine "rebalancing" of the immune system represents a new target in AD therapeutic approach. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/62386 |
DOI: | 10.1016/j.neurobiolaging.2018.12.019 |
ISSN: | 0197-4580 |
e-ISSN: | 1558-1497 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0197458019300090 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1-s2.0-S0197458019300090-main.pdf | 1,43 MB | Adobe PDF | Ver/Abrir |