Antimicrobial activity of new silver (thio)semicarbazone derivatives

Abstract

Background: Among the bioactive metals, silver exhibits the highest toxicity to bacteria, viruses, and other eukaryotic microorganisms. A large number of bioactive Ag(I) coordination compounds with different ligand environment have been reported and, in particular, the derivatives containing weak Ag−O and/or Ag−N bonds can exhibit a high bioactivity, lower light stability, and inferior solubility in water than the compounds with rather strong Ag−S or Ag−P bonds. Herein we describe the synthesis and antimicrobial activity of two new silver(I) compounds that feature the {AgNO} or {AgSO} environments and were derived from semicarbazone and thiosemicarbazone type ligands.