Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/65809
Título: | The biophysics of cell migration: biasing cell motion with feynman ratchets |
Autor(es): | Caballero, David Kundu, Subhas C Reis, R. L. |
Palavras-chave: | Biophysics Cell motility Education Feynman Pedagogy Ratchet Motility Mechanosensing and motility Adaptive primary literature Learning goals Fundamental concepts and techniques Researchers in biophysics-related education Teachers and students of foundational courses in the biophysics-related sciences |
Data: | Jun-2020 |
Editora: | Biophysical Society |
Revista: | The Biophysicist |
Citação: | Caballero D., Kundu S. C., Reis R. L. The Biophysics of Cell Migration: Biasing Cell Motion with Feynman Ratchets, The Biophysicist, Vol. 1, Issue 2, pp. 1-19, doi:10.35459, 2020 |
Resumo(s): | The concepts and frameworks of soft matter physics and the laws of thermodynamics can be used to describe relevant developmental, physiologic, and pathologic events in which directed cell migration is involved, such as in cancer. Typically, this directionality has been associated with the presence of soluble long-range gradients of a chemoattractant, synergizing with many other guidance cues to direct the motion of cells. In particular, physical inputs have been shown to strongly influence cell locomotion. However, this type of cue has been less explored despite the importance in biology. In this paper, we describe recent in vitro works at the interface between physics and biology, showing how the motion of cells can be directed by using gradient-free environments with repeated local asymmetries. This rectification of cell migration, from random to directed, is a process reminiscent of the Feynman ratchet; therefore, this framework can be used to explain the mechanism behind directed cell motion. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/65809 |
DOI: | 10.35459/tbp.2020.000150 |
ISSN: | 2578-6970 |
Versão da editora: | https://meridian.allenpress.com/the-biophysicist/article/1/2/7/439617/The-Biophysics-of-Cell-Migration-Biasing-Cell |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20311-The Biophysicist - Cell bias with Feynman Ratchets.pdf | 1,27 MB | Adobe PDF | Ver/Abrir |