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https://hdl.handle.net/1822/65856
Título: | Cyclosporin A-loaded poly(d,l-lactide) nanoparticles: a promising tool for treating alopecia |
Autor(es): | Fernandes, Bruno Pacheco Matamá, Teresa Gomes, Andreia C Cavaco-Paulo, Artur |
Palavras-chave: | Alopecia Cyclosporin a Hair follicle targeting Hair loss Immunosuppressant Inflammatory skin conditions PLA nanoparticles Skin permeation |
Data: | 17-Jun-2020 |
Editora: | Future Medicine |
Revista: | Nanomedicine |
Citação: | Fernandes, Bruno; Matamá, Teresa; Gomes, Andreia C.; Cavaco-Paulo, Artur, Cyclosporin A-loaded poly(d,l-lactide) nanoparticles: a promising tool for treating alopecia. Nanomedicine, 15(15), 1459-1469, 2020 |
Resumo(s): | Background: Alopecia treatments are scarce and lack efficacy. Cyclosporin A (CsA) has hair growth-inducing properties but its poor cutaneous absorption undermines its use in topical treatments. Aim: Development of a new potential topical treatment of alopecia with CsA. Materials \& methods: CsA-loaded poly(d,l-lactide) (PLA) nanoparticles were obtained and characterized. Skin permeation was evaluated in ex vivo porcine skin. Results: Nanoparticles with good physicochemical stability increased CsA skin permeation/hair follicles accumulation, compared with a noncolloidal formulation. CsA biocompatibility in NCTC2455 keratinocytes (reference skin cell line) was clearly improved when encapsulated in PLA nanoparticles. Conclusion: This work fosters further in vivo investigation of CsA-loaded PLA nanoparticles as a promising new strategy to treat alopecia, a very traumatic, possibly autoimmune, disease. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/65856 |
DOI: | 10.2217/nnm-2020-0089 |
ISSN: | 1743-5889 |
e-ISSN: | 1748-6963 |
Versão da editora: | https://www.futuremedicine.com/journal/nnm |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CBMA - Artigos/Papers DBio - Artigos/Papers |
Ficheiros deste registo:
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document_53806_1.pdf Acesso restrito! | 9,87 MB | Adobe PDF | Ver/Abrir |