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https://hdl.handle.net/1822/66195
Título: | Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems |
Autor(es): | Mahant, Sheefali Rao, Rekha Souto, Eliana B. Nanda, Sanju |
Palavras-chave: | characterization colloidal carriers dermatological hydrogel in vitro in vivo nanoparticles skin |
Data: | 20-Jul-2020 |
Editora: | Taylor and Francis |
Revista: | Expert Opinion on Drug Delivery |
Citação: | Mahant, Sheefali; Rao, Rekha; Souto, Eliana; Nanda, Sanju, Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems. Expert Opinion on Drug Delivery, 17(7), 963-992, 2020 |
Resumo(s): | Introduction The inception of nanostructured lipid carriers (NLCs) proved to be a revolutionary step toward the treatment of dermatological disorders. To uncover its true potential, it is imperative that the system be characterized and evaluated comprehensively. Areas covered The present review has been written to furnish an in-depth account of analytical tools and evaluation procedures under one roof. Besides discussing the challenges of topical delivery and benefits of NLCs, the paper elaborates on their physicochemical characterization. Further, in vitro evaluation of NLCs for dermatological benefits, followed by their evaluation in a hydrogel/cream base is covered. Lastly, disease-specific evaluation of NLC-based formulations is presented. Expert opinion The research endeavors for NLCs have largely focused on the fabrication of NLCs for different bioactives. However, scientific efforts should be aimed toward the lesser explored realm of NLCs, i.e. exploitation of analytical techniques, such as Parelectric spectroscopy, Electron Spin Resonance, and Nuclear Magnetic Resonance spectroscopy. NLCs have been proven for their potential to foster the therapeutic modalities applicable to cutaneous disorders. More attention needs to be devoted to their evaluation for disease-specific parameters. The futuristic steps must involve clinical studies, to lay the path for their commercialization. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66195 |
DOI: | 10.1080/17425247.2020.1772750 |
ISSN: | 1742-5247 |
Versão da editora: | https://www.tandfonline.com/toc/iedd20/current |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
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document_53847_1.pdf Acesso restrito! | 1,2 MB | Adobe PDF | Ver/Abrir |