Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66737
Título: | Magnetoliposomes incorporated in peptide-based hydrogels: towards development of magnetolipogels |
Autor(es): | Veloso, Sérgio Rafael Silva Andrade, Raquel G. D. Ribeiro, Beatriz C. Ferreira, André V. F. Rodrigues, Ana Rita Oliveira Martins, J. A. R. Ferreira, Paula M. T. Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
Palavras-chave: | magnetoliposomes hydrogels magnetolipogels self-assembly fluorescence Förster resonance energy transfer Fö rster resonance energy transfer |
Data: | 2020 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Nanomaterials |
Citação: | Veloso, S.R.S.; Andrade, R.G.D.; Ribeiro, B.C.; Fernandes, A.V.F.; Rodrigues, A.R.O.; Martins, J.A.; Ferreira, P.M.T.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetoliposomes Incorporated in Peptide-Based Hydrogels: Towards Development of Magnetolipogels. Nanomaterials 2020, 10, 1702. DOI:10.3390/nano10091702 |
Resumo(s): | A major problem with magnetogels is the encapsulation of hydrophobic drugs. Magnetoliposomes not only provide these domains but also improve drug stability and avert the aggregation of the magnetic nanoparticles. In this work, two magnetoliposome architectures, solid and aqueous, were combined with supramolecular peptide-based hydrogels, which are of biomedical interest owing to their biocompatibility, easy tunability, and wide array of applications. This proof-of-concept was carried out through combination of magnetoliposomes (loaded with the model drug curcumin and the lipid probe Nile Red) with the hydrogels prior to pH triggered gelation, and fluorescence spectroscopy was used to assess the dynamics of the encapsulated molecules. These systems allow for the encapsulation of a wider array of drugs. Further, the local environment of the encapsulated molecules after gelation is unaffected by the used magnetoliposome architecture. This system design is promising for future developments on drug delivery as it provides a means to independently modify the components and adapt and optimize the design according to the required conditions. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66737 |
DOI: | 10.3390/nano10091702 |
e-ISSN: | 2079-4991 |
Versão da editora: | https://www.mdpi.com/2079-4991/10/9/1702 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
nanomaterials-10-01702.pdf | Documento principal | 2,77 MB | Adobe PDF | Ver/Abrir |
nanomaterials-10-01702-s001.pdf | Material Suplementar | 495,88 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons