Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/67162

TítuloEffects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis
Autor(es)Xavier-Magalhães, Ana
Oliveira, Ana Isabel Ferreira
de Castro, Joana Vieira
Pojo, Marta
Gonçalves, Céline S.
Lourenço, Tatiana
Viana-Pereira, Marta
Costa, Sandra
Linhares, Paulo
Vaz, Rui
Nabiço, Rui
Amorim, Júlia
Pinto, Afonso A
Reis, R. M.
Costa, Bruno Marques
Palavras-chaveAdult
Aged
Aged, 80 and over
Biomarkers, Tumor
Brain Neoplasms
Case-Control Studies
Female
Gene Frequency
Glioma
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
RNA, Long Noncoding
Genetic Predisposition to Disease
HOTAIR
SNP
Rs920778
Rs12826786
Data2017
EditoraSpringer
RevistaJournal of Neuro-Oncology
CitaçãoXavier-Magalhães, A., Oliveira, A. I., de Castro, J. V., Pojo, M., et. al.(2017). Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis. Journal of neuro-oncology, 132(1), 27-34
Resumo(s)Abnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor types. However, the relevance of these HOTAIR SNPs has not been studied in glioma. Here, we report a case-control study comprising 177 Portuguese glioma patients and 199 cancer-free controls. All subjects were genotyped by PCR and restriction fragment length polymorphism (RFLP). No statistically significant differences were found in the genotype or allele distributions of either rs920778 or rs12826786 between glioma patients and controls, suggesting these SNPs are not associated with glioma risk. No significant associations were found between rs920778 variants and HOTAIR expression levels, while rs12826786 CT genotype was associated with increased intratumoral HOTAIR RNA levels when compared to TT genotype (p-value = 0.04). Univariate (Log-rank) and multivariate (Cox proportional) analyses showed both rs920778 CT and rs12826786 CT genotypes were significantly associated with longer overall survival of WHO grade III anaplastic oligodendroglioma patients. Our results suggest that HOTAIR SNPs rs920778 and rs12826786 do not play a significant role in glioma susceptibility, but may be important prognostic factors in anaplastic oligodendroglioma patients. Future studies are warranted to validate and expand these findings, and to further dissect the importance of these SNPs in glioma.
TipoArtigo
URIhttps://hdl.handle.net/1822/67162
DOI10.1007/s11060-016-2345-0
ISSN0167-594X
e-ISSN1573-7373
Arbitragem científicayes
AcessoAcesso restrito UMinho
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Xavier-magalhaes-2017-Effects-of-the-functional-hotair-rs.pdf
Acesso restrito!
738,53 kBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID