Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/67286

TitleEAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees
Author(s)Horwich, A.
Babjuk, M.
Bellmunt, J.
Bruins, H. M.
De Reijke, T. M.
De Santis, M.
Gillessen, S.
James, N.
Maclennan, S.
Figueiredo, Luís Pacheco
et. al.
KeywordsDelphi Technique
Europe
Humans
International Cooperation
Medical Oncology
Neoplasm Staging
Societies, Medical
Stakeholder Participation
Surveys and Questionnaires
Urinary Bladder
Urinary Bladder Neoplasms
Urology
Consensus
Practice Guidelines as Topic
Bladder cancer
Consensus
Delphi
Diagnosis
Treatment
Follow-up
Issue dateNov-2019
PublisherElsevier
JournalAnnals of Oncology
CitationHorwich, A., Babjuk, M., Bellmunt, J., et. al. (2019). EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees. Annals of Oncology, 30(11), 1697-1727
Abstract(s)Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference. Setting: Online Delphi survey and consensus conference. Participants: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management. Outcome measurements and statistical analysis: Statements were ranked by experts according to their level of agreement: 1–3 (disagree), 4–6 (equivocal), 7–9 (agree). A priori (level 1) consensus was defined as 70% agreement and 15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus). Results and limitations: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease and the evolving role of checkpoint inhibitor therapy in metastatic disease. Conclusions: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time where further evidence is available to guide our approach
TypeArticle
URIhttps://hdl.handle.net/1822/67286
DOI10.1093/annonc/mdz296
ISSN0923-7534
e-ISSN1569-8041
Publisher versionhttps://www.annalsofoncology.org/article/S0923-7534(20)32592-8/fulltext
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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