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https://hdl.handle.net/1822/67350
Título: | Definition of immunological nonresponse to antiretroviral therapy: a systematic review |
Autor(es): | Silva, Rita Ribeiro Goios, Ana Kelly, Christine Teixeira, Pedro João, Cristina Horta, Ana Maria Lacerda Morgado Fernandes Carvalho Aboim Correia-Neves, M |
Palavras-chave: | Anti-HIV Agents CD4 Lymphocyte Count HIV Infections Humans Sustained Virologic Response Terminology as Topic Antiretroviral therapy Immune recovery CD4+ T-cell count Immunological nonresponders Systematic review HIV infection |
Data: | 2019 |
Editora: | Lippincott, Williams & Wilkins |
Revista: | Jaids-Journal of Acquired Immune Deficiency Syndromes |
Citação: | Rb-Silva, R., Goios, A., Kelly, C., Teixeira, P., et. al.(2019). Definition of immunological nonresponse to antiretroviral therapy: a systematic review. JAIDS Journal of Acquired Immune Deficiency Syndromes, 82(5), 452-461 |
Resumo(s): | Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4 T-cell counts are heterogeneous, and need revision and summarization. Background: Terms and criteria to classify people living with HIV on antiretroviral therapy who fail to achieve satisfactory CD4+ T-cell counts are heterogeneous, and need revision and summarization. Methods: We performed a systematic review of PubMed original research articles containing a set of predefined terms, published in English between January 2009 and September 2018. The search retrieved initially 1360 studies, of which 103 were eligible. The representative terminology and criteria were extracted and analyzed. Results: Twenty-two terms and 73 criteria to define the condition were identified. The most frequent term was “immunological nonresponders” and the most frequent criterion was “CD4+ T-cell count <350 cells/µL after ≥24 months of virologic suppression.” Most criteria use CD4+ T-cell counts as a surrogate, either as an absolute value before antiretroviral therapy initiation or as a change after a defined period of time. Distinct values and time points were used. Only 9 of the 73 criteria were used by more than one independent research team. Herein we propose 2 criteria that could help to reach a consensus. Conclusions: The high disparity in terms and criteria here reported precludes data aggregation and progression of the knowledge on this condition, because it renders impossible to compare data from different studies. This review will foster the discussion of terms and criteria to achieve a consensual definition. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67350 |
DOI: | 10.1097/QAI.0000000000002157 |
ISSN: | 1525-4135 |
e-ISSN: | 1944-7884 |
Versão da editora: | https://journals.lww.com/jaids/Abstract/2019/12150/Definition_of_Immunological_Nonresponse_to.5.aspx |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Rb-silva-2019-Definition-of-immunological-nonresp.pdf Acesso restrito! | 205,44 kB | Adobe PDF | Ver/Abrir |