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https://hdl.handle.net/1822/67450| Título: | Malignant gliomas: role of platelet-derived growth factor Receptor A (PDGFRA) |
| Autor(es): | Martinho, Olga Reis, R. M. |
| Palavras-chave: | PDGFRA Molecular alterations Gliomas |
| Data: | 2011 |
| Editora: | Springer |
| Citação: | Martinho, O., & Reis, R. M. (2011). Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA). In Tumors of the Central Nervous System, Volume 1 (pp. 109-118). Springer, Dordrecht. |
| Resumo(s): | Platelet-derived growth factor receptor A (PDGFRA), a type III receptor tyrosine kinase, is frequently up-regulated in cancer, constituting therefore an attractive pharmacological target. Several lines of evidence indicate that PDGFRA plays an important role in gliomagenesis. In the present chapter we will discuss the frequency and type of PDGFRA molecular alterations present in malignant gliomas. Furthermore, we will address the implication of such PDGFRA alterations in malignant glioma patients’ therapy response to PDGFRA targeted therapies. |
| Tipo: | Capítulo de livro |
| URI: | https://hdl.handle.net/1822/67450 |
| ISBN: | 978-94-007-0343-8 |
| e-ISBN: | 978-94-007-0344-5 |
| DOI: | 10.1007/978-94-007-0344-5_12 |
| Versão da editora: | https://link.springer.com/chapter/10.1007/978-94-007-0344-5_12 |
| Acesso: | Acesso restrito autor |
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| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| martinho2010.pdf Acesso restrito! | 936,85 kB | Adobe PDF | Ver/Abrir |
