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https://hdl.handle.net/1822/67581| Título: | Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours |
| Autor(es): | Albergaria, André Paredes, Joana Sousa, Bárbara Milanezi, Maria Fernanda Grillo Carneiro, Vítor Bastos, Joana Costa, Sandra Vieira, Daniella Lopes, Nair Lam, Eric W. Lunet, Nuno Schmitt, Fernando |
| Palavras-chave: | Adult Aged Aged, 80 and over Disease-Free Survival Female GATA3 Transcription Factor Hepatocyte Nuclear Factor 3-alpha Humans Immunohistochemistry Middle Aged Prognosis Proportional Hazards Models Receptors, Estrogen Treatment Outcome Gene Expression Regulation, Neoplastic |
| Data: | Jun-2009 |
| Editora: | BioMed Central (BMC) |
| Revista: | Breast Cancer Research |
| Citação: | Albergaria, A., Paredes, J., Sousa, B., Milanezi, F., et. al.(2009). Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours. Breast cancer research, 11(3), R40 |
| Resumo(s): | The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERalpha, both encoding for transcription factors with a potential involvement in the ERalpha-mediated action in breast cancer. The purpose of this study was to explore if the expression of FOXA1 and GATA-3 may provide an opportunity to stratify subsets of patients that could have better outcome, among the ERalpha-negative/poor prognosis breast cancer group. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/67581 |
| DOI: | 10.1186/bcr2327 |
| ISSN: | 1465-5411 |
| e-ISSN: | 1465-542X |
| Versão da editora: | https://link.springer.com/article/10.1186/bcr2327 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Albergaria-2009-Expression-of-foxa-and-gata--in-bre.pdf | 1,45 MB | Adobe PDF | Ver/Abrir |
