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https://hdl.handle.net/1822/67609
Título: | Buruli ulcer disease: prospects for a vaccine |
Autor(es): | Huygen, Kris Adjei, Ohene Affolabi, Dissou Bretzel, Gisela Demangel, Caroline Fleischer, Bernhard Johnson, Roch Christian Pedrosa, Jorge Phanzu, Delphin M. Phillips, Richard O. Pluschke, Gerd Siegmund, Vera Singh, Mahavir van der Werf, Tjip S. Wansbrough-Jones, Mark Portaels, Françoise |
Palavras-chave: | Africa, Western Bacterial Vaccines Buruli Ulcer Humans Incidence Mycobacterium ulcerans Prevalence Mycolactone toxin Vaccine Neglected diseases Review |
Data: | Mai-2009 |
Editora: | Springer |
Revista: | Medical Microbiology and Immunology |
Citação: | Huygen, K., Adjei, O., Affolabi, D., Bretzel, G., et. al.(2009). Buruli ulcer disease: prospects for a vaccine. Medical microbiology and immunology, 198(2), 69 |
Resumo(s): | Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD is a mutilating disease leading to severe disability; it is the third most common mycobacterial infection in immunocompetent people after tuberculosis and leprosy. It is most endemic in West Africa, but cases have been reported from more than 30 countries. Treatment with antibiotics is possible, long-lasting and requires injections; there are cases of treatment failures, and the disease is prone to resistance. A vaccine against M. ulcerans would protect persons at risk in highly endemic areas, and could be used as a therapeutic vaccine to shorten the duration of treatment and prevent relapses. There is considerable evidence supporting the notion that generation of a vaccine is feasible. This article reviews the present state of the art with special emphasis on the immunology of the infection and the prospects for development of a vaccine. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67609 |
DOI: | 10.1007/s00430-009-0109-6 |
ISSN: | 0300-8584 |
e-ISSN: | 1432-1831 |
Versão da editora: | https://link.springer.com/article/10.1007/s00430-009-0109-6 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Huygen-2009-Buruli-ulcer-disease-prospects-for-.pdf Acesso restrito! | 335,83 kB | Adobe PDF | Ver/Abrir |