Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/67666

TítuloDNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population
Autor(es)Costa, Sandra
Pinto, Daniela
Pereira, Deolinda
Rodrigues, Helena
Cameselle-Teijeiro, Jorge
Medeiros, Rui
Schmitt, Fernando
Palavras-chaveAdult
Aged
Aged, 80 and over
Breast neoplasms
DNA repair
DNA-Binding proteins
Female
Gene frequency
Humans
Middle aged
Rad51 recombinase
X-ray Repair Cross Complementing Protein 1
Xeroderma Pigmentosum Group D Protein
Genetic predisposition to disease
Polymorphism, Genetic
Familial
Sporadic
Breast
Risk
XRCC1
XRCC3
RAD51
XPD
polymorphisms
DataJun-2007
EditoraSpringer
RevistaBreast Cancer Research and Treatment
Resumo(s)The purpose of this study was to evaluate the role of polymorphisms in DNA repair genes as genetic indicators of susceptibility to familial and sporadic breast cancer. We analysed DNA samples from 285 breast cancer patients and 442 control subjects, for XRCC1 Arg399Gln, XPD Lys751Gln, RAD51 G135C and XRCC3 Thr241Met polymorphisms using PCR-RFLP. We observed that women carriers of XRCC1 399Gln genotypes and without family history of breast cancer have a protective effect concerning this disease (OR = 0.54 95% CI 0.35-0.84; p = 0.006). Furthermore, we found that carriers of XRCC3 241Met genotypes without FH have an increased susceptibility of breast cancer (OR = 2.21 95% CI 1.42-3.44; p < 0.001). Additionally, we verified an increased risk of breast cancer in women with FH and carrying RAD51 135C genotypes (OR = 2.17 95% CI 1.19-3.98; p = 0.012). Our results suggest XRCC1 Arg399Gln and XRCC3 Thr241Met DNA repair polymorphisms as important biomarkers to sporadic breast cancer susceptibility, as well as, RAD51 G135C polymorphism as a real risk modifier in familial breast cancer cases.
TipoArtigo
URIhttps://hdl.handle.net/1822/67666
DOI10.1007/s10549-006-9364-z
ISSN0167-6806
e-ISSN1573-7217
Versão da editorahttps://link.springer.com/article/10.1007/s10549-006-9364-z
Arbitragem científicayes
AcessoAcesso restrito UMinho
Aparece nas coleções:ICVS - Artigos em revistas internacionais / Papers in international journals

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