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https://hdl.handle.net/1822/67766
Título: | Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia |
Autor(es): | Ruano, Dina Macedo, António Soares, Maria João Valente, José Azevedo, Maria Helena Pato, Carlos Hutz, Mara Helena Gama, Clarissa S. Lobato, Maria Inês Belmonte-de-Abreu, Paulo Heutink, Peter Palha, Joana Almeida |
Palavras-chave: | Alleles Brazil Case-Control Studies Family Female Genetic Predisposition to Disease Genotype Haplotypes Humans Intramolecular Oxidoreductases Lipocalins Male Polymorphism, Single Nucleotide Portugal Prostaglandin D2 Schizophrenia PTGDS Retinoids Thyroid hormones Prostaglandins Lipids |
Data: | Jul-2007 |
Editora: | Wiley |
Revista: | American Journal of Medical Genetics Part B-Neuropsychiatric Genetics |
Citação: | Ruano, D., Macedo, A., Soares, M. J., Valente, J., et. al.(2007). Family‐based and case‐control studies reveal no association of lipocalin‐type prostaglandin D2 synthase with schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144(5), 642-646 |
Resumo(s): | Several observations point to the involvement of disturbed lipid biology in schizophrenia. Reduced response to niacin flushing test, which involves vasodilatation induced by prostaglandin D2 (PGD2), is among the evidences, together with decreased CSF levels of lipocalin-type prostaglandin D2 synthase (PTGDS), the enzyme responsible for the synthesis of PGD2 in the brain. Since PTGDS is also a carrier for lipophilic molecules such as retinoids and thyroid hormones, altered PTGDS levels might influence both PGD2-mediated signaling, and vitamin A and thyroid hormone availability. To test whether genetic variants of PTGDS are involved in the etiology of schizophrenia, we searched for variants in the coding and regulatory regions of the gene. We identified four previously described polymorphisms. Using two case-control samples from Portugal and Brazil, none of the polymorphisms tested was associated with the disease. In addition, no transmission distortion was observed in an independent parents-offspring sample from the Azorean Islands. Our data do not support the involvement of the PTGDS gene in the etiology of schizophrenia. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/67766 |
DOI: | 10.1002/ajmg.b.30477 |
ISSN: | 1552-4841 |
e-ISSN: | 1552-485X |
Versão da editora: | https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.b.30477 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Ruano-2007-Family-based-and-case-control-studi.pdf Acesso restrito! | 74,72 kB | Adobe PDF | Ver/Abrir |