Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68160
Título: | Haemocompatibility test of simple Magnetic Nanoparticles using the distribution of deformed RBCs |
Autor(es): | Lage, T. Faustino, V. Rodrigues, Raquel Oliveira Lima, Rui Alberto Madeira Macedo Minas, Graça |
Data: | 2019 |
Editora: | Institute of Electrical and Electronics Engineers Inc. |
Resumo(s): | Haemocompatibility of nanoparticles is usually evaluated by hemolysis. However, hemolysis assessment does not measure the dysfunctional erythrocytes with pathological changes on the unbroken cellular membrane. This paper presents a microfluidic tool based on a constriction channel with a hyperbolic-shaped contraction capable of evaluating the biocompatibility and toxicity impact of magnetic nanoparticles (MNPs). The aim of this study is to evaluate the deformation index of red blood cells (RBCs) that have different concentrations of MNPs and their distribution on the microchannel. The results showed that MNPs affected the deformability of RBCs, as long as the MNPs concentration increases, however with the increase of the temperature, that dependence between MNP concentration and deformability decreases. |
Tipo: | Artigo em ata de conferência |
URI: | https://hdl.handle.net/1822/68160 |
ISBN: | 9781538685068 |
DOI: | 10.1109/ENBENG.2019.8692543 |
Versão da editora: | https://ieeexplore.ieee.org/document/8692543 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CMEMS - Artigos em livros de atas/Papers in proceedings DEI - Artigos em atas de congressos internacionais MEtRICs - Artigos em livros de atas/Papers in proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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P2-6ENBE-Proceedings-2019.pdf Acesso restrito! | 2,93 MB | Adobe PDF | Ver/Abrir |