Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/68246

TitlePatterned piezoelectric scaffolds for osteogenic differentiation
Author(s)Almeida, Teresa Isabel Marques
Cardoso, Vanessa Fernandes
Gama, F. M.
Lanceros-Méndez, S.
Ribeiro, Clarisse
Keywordspiezoelectric
electroactive
patterning
cell differentiation
bone tissue engineering
Issue date2020
PublisherMultidisciplinary Digital Publishing Institute
JournalInternational Journal of Molecular Sciences
CitationMarques-Almeida, T.; Cardoso, V.F.; Gama, M.; Lanceros-Mendez, S.; Ribeiro, C. Patterned Piezoelectric Scaffolds for Osteogenic Differentiation. Int. J. Mol. Sci. 2020, 21, 8352. DOI: 10.3390/ijms21218352
Abstract(s)The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration.
TypeArticle
URIhttps://hdl.handle.net/1822/68246
DOI10.3390/ijms21218352
ISSN1661-6596
e-ISSN1422-0067
Publisher versionhttps://www.mdpi.com/1422-0067/21/21/8352
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
FUNCTIONAL AND SMART MATERIALS AND SURFACES FOR ADVANCED APPLICATIONS (2018 - ...)
CMEMS - Artigos em revistas internacionais/Papers in international journals

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