Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68246
Título: | Patterned piezoelectric scaffolds for osteogenic differentiation |
Autor(es): | Almeida, Teresa Isabel Marques Cardoso, Vanessa Fernandes Gama, F. M. Lanceros-Méndez, S. Ribeiro, Clarisse |
Palavras-chave: | piezoelectric electroactive patterning cell differentiation bone tissue engineering |
Data: | 2020 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | International Journal of Molecular Sciences |
Citação: | Marques-Almeida, T.; Cardoso, V.F.; Gama, M.; Lanceros-Mendez, S.; Ribeiro, C. Patterned Piezoelectric Scaffolds for Osteogenic Differentiation. Int. J. Mol. Sci. 2020, 21, 8352. DOI: 10.3390/ijms21218352 |
Resumo(s): | The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/68246 |
DOI: | 10.3390/ijms21218352 |
ISSN: | 1661-6596 |
e-ISSN: | 1422-0067 |
Versão da editora: | https://www.mdpi.com/1422-0067/21/21/8352 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-21-08352.pdf | 3,2 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons