Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68246
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Almeida, Teresa Isabel Marques | por |
dc.contributor.author | Cardoso, Vanessa Fernandes | por |
dc.contributor.author | Gama, F. M. | por |
dc.contributor.author | Lanceros-Méndez, S. | por |
dc.contributor.author | Ribeiro, Clarisse | por |
dc.date.accessioned | 2020-11-19T11:23:54Z | - |
dc.date.available | 2020-11-19T11:23:54Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Marques-Almeida, T.; Cardoso, V.F.; Gama, M.; Lanceros-Mendez, S.; Ribeiro, C. Patterned Piezoelectric Scaffolds for Osteogenic Differentiation. Int. J. Mol. Sci. 2020, 21, 8352. DOI: 10.3390/ijms21218352 | por |
dc.identifier.issn | 1661-6596 | por |
dc.identifier.uri | https://hdl.handle.net/1822/68246 | - |
dc.description.abstract | The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and differentiation of bone cells. For that, micropatterned P(VDF-TrFE) scaffolds were produced by lithography in the form of arrays of lines and hexagons and then tested for cell proliferation and differentiation of pre-osteoblast cell line. Results show that more anisotropic surface microstructures promote bone differentiation without the need of further biochemical stimulation. Thus, the combination of specific patterns with the inherent electroactivity of materials provides a promising platform for bone regeneration. | por |
dc.description.sponsorship | This work was supported by national funds through the Fundação para a Ciência e Tecnologia (FCT) and by ERDF through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) in the framework of the Strategic Programs UID/FIS/04650/2020 and UIDB/04436/2020 and projects PTDC/EMD-EMD/28159/2017 and PTDC/BTM-MAT/28237/2017. TA thank FCT for the grant SFRH/BD/141136/2018 and CR thanks the FCT for the contract under the Stimulus of Scientific Employment (DL57/2016 junior researcher contract). Finally, the authors acknowledge funding by Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033 and from the Basque Government Industry and Education Departments under the ELKARTEK and PIBA (PIBA-2018-06) programs, respectively. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | UID/FIS/04650/2020 | por |
dc.relation | UIDB/04436/2020 | por |
dc.relation | PTDC/EMD-EMD/28159/2017 | por |
dc.relation | PTDC/BTM-MAT/28237/2017 | por |
dc.relation | SFRH/BD/141136/2018 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | piezoelectric | por |
dc.subject | electroactive | por |
dc.subject | patterning | por |
dc.subject | cell differentiation | por |
dc.subject | bone tissue engineering | por |
dc.title | Patterned piezoelectric scaffolds for osteogenic differentiation | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/21/21/8352 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 8 | por |
oaire.citationIssue | 21 | por |
oaire.citationVolume | 21 | por |
dc.date.updated | 2020-11-12T14:13:28Z | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.doi | 10.3390/ijms21218352 | por |
dc.identifier.pmid | 33171761 | por |
dc.subject.fos | Ciências Naturais::Ciências Físicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Molecular Sciences | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ijms-21-08352.pdf | 3,2 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons