Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/68285
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Campo DC | Valor | Idioma |
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dc.contributor.author | Vieira, Sara Filipa Fontoura | por |
dc.contributor.author | Ferreira, Helena Susana Costa Machado | por |
dc.contributor.author | Neves, N. M. | por |
dc.date.accessioned | 2020-11-23T15:17:29Z | - |
dc.date.available | 2020-11-23T15:17:29Z | - |
dc.date.issued | 2020-11 | - |
dc.date.submitted | 2020-10 | - |
dc.identifier.citation | Vieira, S.F.; Ferreira, H.; Neves, N.M. Antioxidant and Anti-Inflammatory Activities of Cytocompatible Salvia officinalis Extracts: A Comparison between Traditional and Soxhlet Extraction. Antioxidants 2020, 9, 1157. DOI: 10.3390/antiox9111157 | por |
dc.identifier.issn | 2076-3921 | por |
dc.identifier.uri | https://hdl.handle.net/1822/68285 | - |
dc.description.abstract | Chronic inflammation is characterized by an overproduction of several inflammatory mediators (e.g., reactive species and interleukins -IL) that play a central role in numerous diseases. The available therapies are often associated with serious side effects and, consequently, the need for safer drugs is of utmost importance. A plant traditionally used in the treatment of inflammatory conditions is Salvia officinalis. Therefore, conventional maceration and infusion of its leaves were performed to obtain hydroethanolic (HE-T) and aqueous extracts (AE-T), respectively. Their efficacy was compared to soxhlet extracts, namely aqueous (AE-S), hydroethanolic (HE-S), and ethanolic extracts (EE-S). Thin-layer chromatography demonstrated the presence of rosmarinic acid, carnosol, and/or carnosic acid in the different extracts. Generally, soxhlet provided extracts with higher antioxidant activities than traditional extraction. Moreover, under an inflammatory scenario, EE-S were the most effective, followed by HE-S, HE-T, AE-T, and AE-S, in the reduction of IL-6 and TNF-α production. Interestingly, the extracts presented higher or similar anti-inflammatory activity than diclofenac, salicylic acid, and celecoxib. In conclusion, the extraction method and the solvents of extraction influenced the antioxidant activity, but mainly the anti-inflammatory activity of the extracts. Therefore, this natural resource can enable the development of effective treatments for oxidative stress and inflammatory diseases. | eng |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (FCT) to the PhD grant of SV (PD/BD/135246/2017) and the projects PATH (PD/00169/2013), Cells4_IDs (PTDC/BTM-SAL/28882/2017) and the NORTE 2020 Structured Project, cofunded by Norte2020 (NORTE-01-0145-FEDER-000021) | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | PD/BD/135246/2017 | - |
dc.relation | PD/00169/2013 | - |
dc.relation | PTDC/BTM-SAL/28882/2017 | - |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Anti-inflammatory activity | por |
dc.subject | Antioxidant activity | por |
dc.subject | Cytocompatibility | por |
dc.subject | Reactive oxygen and nitrogen species | por |
dc.subject | Salvia officinalis | por |
dc.subject | Soxhlet extraction | por |
dc.subject | Traditional extraction | por |
dc.title | Antioxidant and anti-inflammatory activities of cytocompatible Salvia officinalis extracts: A comparison between traditional and soxhlet extraction | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2076-3921/9/11/1157 | por |
dc.comments | http://3bs.uminho.pt/node/20424 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 25 | por |
oaire.citationIssue | 11 | por |
oaire.citationVolume | 9 | por |
dc.date.updated | 2020-11-23T09:30:22Z | - |
dc.identifier.doi | 10.3390/antiox9111157 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Antioxidants | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20424-antioxidants-09-01157.pdf | 6,65 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons