Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/68607

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dc.contributor.authorRebelo, Rita Daniela Nogueirapor
dc.contributor.authorPadrão, Jorgepor
dc.contributor.authorFernandes, Margarida Maria Macedopor
dc.contributor.authorCarvalho, S.por
dc.contributor.authorHenriques, Marianapor
dc.contributor.authorZille, Andreapor
dc.contributor.authorFangueiro, Raúlpor
dc.date.accessioned2020-12-18T16:51:12Z-
dc.date.available2020-12-18T16:51:12Z-
dc.date.issued2020-12-
dc.date.submitted2020-11-
dc.identifier.citationRebelo, R.; Padrão, J.; Fernandes, M.M.; Carvalho, S.; Henriques, M.; Zille, A.; Fangueiro, R. Aging Effect on Functionalized Silver-Based Nanocoating Braided Coronary Stents. Coatings 2020, 10, 1234.por
dc.identifier.urihttps://hdl.handle.net/1822/68607-
dc.description.abstractA previously developed fiber-based polyester (PES) stent, with mechanical properties comparable to commercial nitinol stents, was coated with metallic silver (Ag0) and silver oxides (AgxO) thin films through direct current (DC) magnetron sputtering. Ag0 and AgxO coatings provide antimicrobial properties to the stents to minimize the occurrence of coronary stent infections. Nevertheless, the stent interacts with the atmosphere and then with the biological fluids and may lead to the generation of silver species with diminished antimicrobial efficiency and/or prone to induce cytotoxicity. Therefore, stent coating nanostructures aged 3 months were thoroughly analyzed by X-ray photoelectron spectroscopy (XPS) and their antimicrobial and cytotoxicity properties were assessed. Aging led to the presence of silver carbonate and bicarbonate as well as chemisorbed oxygen species in Ag0 and AgxO coatings. Bactericidal efficacy was tested against an important nosocomial bacterium, particularly associated to indwelling devices: Staphylococcus epidermidis. Aged Ag0 and AgxO coating presented a Log reduction of 1 and 2 at their surface; respectively. However, aged stents were able to induce a Log reduction of 2 (Ag0) and 4 (AgxO) on the surrounding medium. Only aged AgxO stent was able to provide a mild reduction of the bacterium at its surface and a clear antimicrobial effect (Log reduction >3) within its vicinity. More importantly, both aged Ag0 and AgxO stents were shown to be compatible with fibroblasts cells indicating that they can be safely used as indwelling devices, despite the aging effectpor
dc.description.sponsorshipThis work was funded by FEDER funds through the Operational Competitiveness ProgramCOMPETE and by National Funds through Fundacao para a Ciencia e Tecnologia (FCT)-under the projects PTDC/CTM-TEX/28295/2017 and UID/CTM/00264/2019.por
dc.language.isoengpor
dc.publisherMDPI Publishingpor
dc.relationPTDC/CTM-TEX/28295/2017-
dc.relationUID/CTM/00264/2019-
dc.rightsopenAccesspor
dc.subjectStentpor
dc.subjectSilverpor
dc.subjectTextilepor
dc.subjectDirect current magnetron sputteringpor
dc.subjectX-ray photoelectron spectroscopypor
dc.subjectBactericidalpor
dc.subjectCytotoxicitypor
dc.titleAging effect on functionalized silver-based nanocoating braided coronary stentspor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.mdpi.com/2079-6412/10/12/1234#citepor
oaire.citationStartPage1234por
oaire.citationEndPage17por
oaire.citationIssue12por
oaire.citationVolume10por
dc.identifier.eissn2079-6412por
dc.identifier.doi10.3390/coatings10121234por
dc.subject.fosEngenharia e Tecnologia::Engenharia dos Materiaispor
dc.subject.wosScience & Technologypor
sdum.journalCoatingspor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
DET/2C2T - Artigos em revistas internacionais com arbitragem científica

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