Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/70183

TítuloEugenol-containing essential oils loaded onto Chitosan/Polyvinyl alcohol blended films and their ability to eradicate Staphylococcus aureus or Pseudomonas aeruginosa from infected microenvironments
Autor(es)Antunes, Joana Isabel Costa
Tavares, Tânia Daniela Eugénio
Ferreira, Marta Albertina Fernandes
Teixeira, Marta O.
Homem, Natália Cândido
Amorim, M. T. Pessoa de
Felgueiras, Helena Prado
Palavras-chaveBactericidal
Chitosan
Essential Oils
Blended Films
Wound Dressings
Wound Healing
Data2-Fev-2021
EditoraMDPI Publishing
RevistaPharmaceutics
CitaçãoAntunes, J. C., Tavares, T. D., Teixeira, M. A., Teixeira, M. O., et. al. (2021). Eugenol-Containing Essential Oils Loaded onto Chitosan/Polyvinyl Alcohol Blended Films and Their Ability to Eradicate Staphylococcus aureus or Pseudomonas aeruginosa from Infected Microenvironments. Pharmaceutics, 13(2), 195
Resumo(s)Chronic wounds (CW) create numerous entryways for pathogen invasion and prosperity, further damaging host tissue and hindering its remodeling and repair. Essential oils (EOs) exert quick and efficient antimicrobial (AM) action, unlikely to induce bacterial resistance. Cinnamon leaf and clove oils (CLO and CO) display strong AM activity, namely against Staphylococcus aureus and Pseudomonas aeruginosa. Chitosan (CS) is a natural and biodegradable cationic polysaccharide, also widely known for its AM features. CS and poly (vinyl alcohol) (PVA) films were prepared (ratio 30/70 w/w; 9 wt%) by the solvent casting and phase inversion method. The film's thermal stability and chemical composition data reinforced polymer blending and EO entrapment. Films were supplemented with 1 and 10 wt% of EO in relation to total polymeric mass. The film thickness and degree of swelling (DS) tended to increase with EO content, particularly with 10 wt % CLO (* p < 0.05). UV-visible absorbance scans in the 250-320 cm-1 region confirmed the successful uptake of CLO and CO into CS/PVA films, particularly with films loaded with 10 wt% EO that contained 5.30/5.32 times more CLO/CO than films supplemented with 1 wt% EO. AM testing revealed that CS films alone were effective against both bacteria and capable of eradicating all P. aeruginosa within the hour (*** p < 0.001). Still, loaded CS/PVA films showed significantly improved AM traits in relation to unloaded films within 2 h of contact. This study is a first proof of concept that CLO and CO can be dispersed into CS/PVA films and show bactericidal effects, particularly against S. aureus, this way paving the way for efficient CW therapeutics.
TipoArtigo
URIhttps://hdl.handle.net/1822/70183
DOI10.3390/pharmaceutics13020195
e-ISSN1999-4923
Versão da editorahttps://www.mdpi.com/1999-4923/13/2/195
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:DET/2C2T - Artigos em revistas internacionais com arbitragem científica

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
2021 Pharmaceutics Joana.pdf4,04 MBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID