Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/71133

TitleNanoemulsions for enhancement of curcumin bioavailability and their safety evaluation: effect of emulsifier type
Author(s)Gonçalves, Raquel Filipa Silva
Martins, Joana T.
Abrunhosa, Luís
Vicente, A. A.
Pinheiro, A. C.
Keywordsnanoemulsions
lecithin
rhamnolipids
Tween® 80
In vitro static digestion
cytotoxicity
Tween(&#174)
80
Issue date2021
PublisherMDPI
JournalNanomaterials
CitationGonçalves, Raquel F. S.; Martins, Joana T.; Abrunhosa, Luís; Vicente, António A.; Pinheiro, Ana Cristina, Nanoemulsions for enhancement of curcumin bioavailability and their safety evaluation: effect of emulsifier type. Nanomaterials, 11(3), 815, 2021
Abstract(s)This work aimed at evaluating the effects of different emulsifiers on curcumin-loaded nanoemulsions behavior during digestion, its safety and absorption, to develop nanoemulsions that provide safety and improved curcumin functionality. Nanoemulsions (NEs) were produced using two bio-based (lecithin (LEC) and rhamnolipids (RHAM)) and one synthetic (Tween®80 (TWE)) emulsifier at similar concentrations. Different NEs were subjected to in vitro digestion. The cytotoxicity and permeability tests were performed in Caco-2 cells. NE_TWE were stable during all phases of in vitro digestion, whereas NE_LEC and NE_RHAM were found to be unstable from the gastric phase. NE_TWE showed 100% of free fatty acids released, followed by NE_RHAM and NE_LEC. Curcumins bioaccessibility and stability increased in the following order: NE_LEC > NE_RHAM > NE_TWE. NE_LEC and NE_TWE did not show cytotoxic effects in any of the concentrations tested, while NE_RHAM presented high cytotoxicity in all concentrations tested. The apparent permeability coefficients were determined for NE_LEC and NE_TWE; however, the results were not statistically different. These results showed that the emulsifier used has a high impact on nanoemulsions behavior under the digestion process and on their cytotoxicity. This work contributed to the state-of-the-arts progress on the development of safer curcumin delivery systems with improved functionality, particularly regarding the proper selection of ingredients to produce said systems.
TypeArticle
URIhttps://hdl.handle.net/1822/71133
DOI10.3390/nano11030815
ISSN20794991
Publisher versionhttps://www.mdpi.com/2079-4991/11/3/815
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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