Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71133
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Gonçalves, Raquel Filipa Silva | por |
dc.contributor.author | Martins, Joana T. | por |
dc.contributor.author | Abrunhosa, Luís | por |
dc.contributor.author | Vicente, A. A. | por |
dc.contributor.author | Pinheiro, A. C. | por |
dc.date.accessioned | 2021-03-31T01:16:55Z | - |
dc.date.available | 2021-03-31T01:16:55Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Gonçalves, Raquel F. S.; Martins, Joana T.; Abrunhosa, Luís; Vicente, António A.; Pinheiro, Ana Cristina, Nanoemulsions for enhancement of curcumin bioavailability and their safety evaluation: effect of emulsifier type. Nanomaterials, 11(3), 815, 2021 | por |
dc.identifier.issn | 20794991 | por |
dc.identifier.uri | https://hdl.handle.net/1822/71133 | - |
dc.description.abstract | This work aimed at evaluating the effects of different emulsifiers on curcumin-loaded nanoemulsions behavior during digestion, its safety and absorption, to develop nanoemulsions that provide safety and improved curcumin functionality. Nanoemulsions (NEs) were produced using two bio-based (lecithin (LEC) and rhamnolipids (RHAM)) and one synthetic (Tween®80 (TWE)) emulsifier at similar concentrations. Different NEs were subjected to in vitro digestion. The cytotoxicity and permeability tests were performed in Caco-2 cells. NE_TWE were stable during all phases of in vitro digestion, whereas NE_LEC and NE_RHAM were found to be unstable from the gastric phase. NE_TWE showed 100% of free fatty acids released, followed by NE_RHAM and NE_LEC. Curcumins bioaccessibility and stability increased in the following order: NE_LEC > NE_RHAM > NE_TWE. NE_LEC and NE_TWE did not show cytotoxic effects in any of the concentrations tested, while NE_RHAM presented high cytotoxicity in all concentrations tested. The apparent permeability coefficients were determined for NE_LEC and NE_TWE; however, the results were not statistically different. These results showed that the emulsifier used has a high impact on nanoemulsions behavior under the digestion process and on their cytotoxicity. This work contributed to the state-of-the-arts progress on the development of safer curcumin delivery systems with improved functionality, particularly regarding the proper selection of ingredients to produce said systems. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and under the scope of project PTDC/AGR-TEC/5215/2014. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | PTDC/AGR-TEC/5215/2014 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | nanoemulsions | por |
dc.subject | lecithin | por |
dc.subject | rhamnolipids | por |
dc.subject | Tween® 80 | por |
dc.subject | In vitro static digestion | por |
dc.subject | cytotoxicity | por |
dc.subject | Tween(®) | por |
dc.subject | 80 | por |
dc.title | Nanoemulsions for enhancement of curcumin bioavailability and their safety evaluation: effect of emulsifier type | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2079-4991/11/3/815 | por |
dc.comments | CEB54354 | por |
oaire.citationStartPage | 815 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 11 | por |
dc.date.updated | 2021-03-30T23:10:39Z | - |
dc.identifier.doi | 10.3390/nano11030815 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nanomaterials | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54354_1.pdf | 2,64 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons