Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/71847

TítuloAdditive manufactured porous biomaterials targeting orthopedic implants: a suitable combination of mechanical, physical and topological properties
Autor(es)Bartolomeu, Flávio
Dourado, N.
Pereira, F.
Alves, N.
Miranda, G.
Silva, Filipe Samuel
Palavras-chaveAnimals
Arthroplasty, Replacement, Hip
Biocompatible Materials
Biomechanical Phenomena
Cell Line
Cell Survival
Computer-Aided Design
Elastic Modulus
Fibroblasts
Materials Testing
Mice
Porosity
Surface Properties
Titanium
Prostheses and Implants
Selective laser melting
Ti6Al4V
Cellular structures
Design tools
DataFev-2020
EditoraElsevier
RevistaMaterials Science & Engineering: C Materials for Biological Applications
Resumo(s)Orthopedic implants are under incessant advancement to improve their interactions with surrounding bone tissue aiming to ensure successful outcomes for patients. A successful biological interaction between implant and surrounding bone depends on the combination of mechanical, physical and topological properties. Hence, Ti6Al4V cellular structures appear as very promising solutions towards the improvement of conventional orthopedic implants. This work addresses a set of fundamental tools that allow improving the design of Ti6Al4V cellular structures produced by Selective Laser Melting (SLM). Three-point bending tests were carried out to estimate the elastic modulus of the produced structures. Morphological analysis allowed to evaluate the dimensional differences that were noticed between the model CAD and the SLM structures. Finite element models (adjusted CAD) were constructed with the experimentally obtained dimensions to replicate the mechanical response of the SLM structures. Linear correlations were systematically found for the dimensions of the SLM structures as a function of the designed model CAD dimensions. This has also been observed for the measured porosities as a function of the designed CAD models. This data can be used in further FE analyses as design guidelines to help engineers fabricating near-net-shape SLM Ti6Al4V cellular structures. Besides, polished and sandblasted surface treatments performed on the Ti6Al4V cellular structures allowed to obtain suitable properties regarding roughness and wettability when compared to as-produced surfaces. The capillarity tests showed that all the analyzed Ti6Al4V structures are able to transport fluid along its structure. The cell viability tests demonstrate Ti6Al4V cellular structures SLM produced did not release toxic substances to the medium, indicating that these structures can assure a suitable environment for cells to proliferate and attach. This study proposes a design methodology for Ti6Al4V cellular structures, that owe suitable mechanical properties but also provide a proper combination of porosity, roughness, wettability, capillarity and cell viability, all of them relevant for orthopedic applications. A Ti6Al4V cellular structured hip implant prototype gathering the suitable features addressed in this study was successfully SLM-produced.
TipoArtigo
URIhttps://hdl.handle.net/1822/71847
DOI10.1016/j.msec.2019.110342
ISSN0928-4931
e-ISSN1873-0191
Versão da editorahttps://www.sciencedirect.com/science/article/pii/S0928493119300153
Arbitragem científicayes
AcessoAcesso restrito UMinho
Aparece nas coleções:CMEMS - Artigos em revistas internacionais/Papers in international journals
DEM - Artigos em revistas de circulação internacional com arbitragem científica

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56 - MSEC Bar-Dou-Per-Alv-Mir-Sil (2020).pdf
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Additive manufactured porous biomaterials targeting orthopedic implants: A suitable combination of mechanical, physical and topological properties4,04 MBAdobe PDFVer/Abrir

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