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https://hdl.handle.net/1822/72354
Título: | Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise and the Hare” |
Autor(es): | Santos-Pereira, Ana Magalhães, Carlos André Rodrigues Araújo, Pedro M. M. Osório, Nuno S. |
Palavras-chave: | HIV-1 Mycobacterium tuberculosis Evolutionary genetics Lineage Subtype Genetic diversity Tuberculosis AIDS Mycobacterium |
Data: | 2021 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Microorganisms |
Citação: | Santos-Pereira, A.; Magalhães, C.; Araújo, P.M.M.; Osório, N.S. Evolutionary Genetics of Mycobacterium Tuberculosis and HIV-1: “The Tortoise and the Hare”. Microorganisms 2021, 9, 147. https://doi.org/10.3390/microorganisms9010147 |
Resumo(s): | The already enormous burden caused by Mycobacterium tuberculosis and Human Immunodeficiency Virus type 1 (HIV-1) alone is aggravated by co-infection. Despite obvious differences in the rate of evolution comparing these two human pathogens, genetic diversity plays an important role in the success of both. The extreme evolutionary dynamics of HIV-1 is in the basis of a robust capacity to evade immune responses, to generate drug-resistance and to diversify the populationlevel reservoir of M group viral subtypes. Compared to HIV-1 and other retroviruses, M. tuberculosis generates minute levels of genetic diversity within the host. However, emerging whole-genome sequencing data show that the M. tuberculosis complex contains at least nine human-adapted phylogenetic lineages. This level of genetic diversity results in differences in M. tuberculosis interactions with the host immune system, virulence and drug resistance propensity. In co-infected individuals, HIV-1 and M. tuberculosis are likely to co-colonize host cells. However, the evolutionary impact of the interaction between the host, the slowly evolving M. tuberculosis bacteria and the HIV-1 viral “mutant cloud” is poorly understood. These evolutionary dynamics, at the cellular niche of monocytes/macrophages, are also discussed and proposed as a relevant future research topic in the context of single-cell sequencing. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/72354 |
DOI: | 10.3390/microorganisms9010147 |
e-ISSN: | 2076-2607 |
Versão da editora: | https://www.mdpi.com/2076-2607/9/1/147 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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microorganisms-09-00147-v2.pdf | 4,97 MB | Adobe PDF | Ver/Abrir |