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https://hdl.handle.net/1822/74070| Título: | Exploring innovative Leishmaniasis treatment: drug targets from pre-clinical to clinical findings |
| Autor(es): | Santana, Wanessa de Oliveira, Simone S. C. Ramos, Mariana H. Santos, André L. S. Dolabella, Silvio S. Souto, Eliana B. Severino, Patrícia Jain, Sona |
| Palavras-chave: | Leishmaniasis New targets Pre-clinical Clinical Drug repurposing |
| Data: | Set-2021 |
| Editora: | Wiley-Blackwell |
| Revista: | Chemistry & Biodiversity |
| Citação: | Santana, Wanessa; de Oliveira, Simone S. C.; Ramos, Mariana H.; Santos, André L. S.; Dolabella, Silvio S.; Souto, Eliana; Severino, Patrícia; Jain, Sona, Exploring innovative Leishmaniasis treatment: drug targets from pre-clinical to clinical findings. Chemistry & Biodiversity, 18(9), e2100336, 2021 |
| Resumo(s): | Leishmaniasis is a group of tropical diseases caused by parasitic protozoa belonging to the genus Leishmania. The disease is categorized in cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). The conventional treatment is complex and can present high toxicity and therapeutic failures. Thus, there is a continuing need to develop new treatments. In this review, we focus on the novel molecules described in the literature with potential leishmanicidal activity, categorizing them in pre-clinical (invitro, invivo), drug repurposing and clinical research. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/74070 |
| DOI: | 10.1002/cbdv.202100336 |
| ISSN: | 1612-1872 |
| Versão da editora: | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100336 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| document_54590_1.pdf | 3,56 MB | Adobe PDF | Ver/Abrir |
