Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/74420

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dc.contributor.authorCaldas, Ana R.por
dc.contributor.authorFaria, Maria J.por
dc.contributor.authorRibeiro, Arturpor
dc.contributor.authorMachado, Raulpor
dc.contributor.authorGonçalves, Hugopor
dc.contributor.authorGomes, Andreia Cpor
dc.contributor.authorSoares, Graça M. B.por
dc.contributor.authorLopes, Carla M.por
dc.contributor.authorLúcio, Marlenepor
dc.date.accessioned2021-10-19T10:50:44Z-
dc.date.issued2021-11-15-
dc.identifier.citationCaldas, Ana R.; Faria, Maria J.; Ribeiro, Artur; Machado, Raul; Gonçalves, Hugo; Gomes, Andreia C.; Soares, Graça M. B.; Lopes, Carla M.; Lúcio, Marlene, Avobenzone-loaded and omega-3-enriched lipid formulations for production of UV blocking sunscreen gels and textiles. Journal of Molecular Liquids, 342(116965), 2021por
dc.identifier.issn0167-7322por
dc.identifier.urihttps://hdl.handle.net/1822/74420-
dc.description.abstractGiven the growing harmful effects of ultraviolet (UV) radiation there is an urgent need to develop effective strategies to prevent skin damages. Therefore, hydrogel or cotton and wool fabrics were impregnated with avobenzone (AVO)-loaded and omega-3 (3)-enriched lipid formulations (liposomes LIP, nanostructured lipid carriers NLC and solid lipid nanoparticles SLN) to obtain UV blocking sunscreen gel or functional textiles. To evaluate the physicochemical characteristics of AVO and the sun blocking performance of the formulations incorporated in hydrogels or textiles, in silico and in vitro studies were conducted. In silico studies indicated that AVO can permeate the epithelium, and lipid formulations could be a promising strategy for incorporating and retaining AVO. Furthermore, all lipid formulations showed an entrapment efficiency of AVO of ca. 100 % and a loading capacity between 712 %. The presence of AVO was confirmed by ATR-FTIR and SEM analysis. In vitro release profiles showed that the UV filter was almost totally retained within the lipid formulations (release of only 4.2 ± 2.5 % at 6 h) with similar results obtained for textiles. After assessing the cytotoxicity, cationic formulations loaded with AVO showed to be cytotoxic in a human keratinocyte cell line (NCTC 2544 cells) as opposed to AVO-loaded anionic formulations after 24 h. Photodegradation studies demonstrated that lipid formulations have photoprotective properties by stabilizing AVO but the photoprotective role could not be attributed to 3 despite its antioxidant effect evaluated by ATR-FTIR. Overall, it is possible to conclude that SLN and NLC were more effective as UV protectors than LIP, and that each formulation can have different applications. Negatively charged NLC and SLN can be used for UV protection in contact with the skin either in sunscreen gel or clothing, while positively charged NLC and SLN should be reserved as UV protectors of tissues not in contact with skin (e.g., umbrellas, curtains, etc.).por
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e Tecnologia (FCT I.P.) in the framework of the Strategic Funding [UID/FIS/04650/2019 and UIDB/04469/2020], “Contrato-Programa” UIDB/ and by the project CONCERT [POCI-01-0145-FEDER-032651 and PTDC/NAN-MAT/326512017], co-financed by the European Regional Development Fund (ERDF), through COMPETE 2020, under Portugal 2020, and FCT I.P. Marlene Lúcio thanks FCT and ERDF for doctoral position [CTTI-150/18-CF (1)] in the scope of the project CONCERT. Raul Machado acknowledges FCT I.P. for funding within the Scientific Employment Stimulus instrument (CEECIND/00526/2018) The authors also would like to express appreciation for the support of the sponsors [Programme - COMPETE and by national funds through FCT – Foundation for Science and Technology within the scope of the project POCI-01-0145-FEDER-007136]. Maria João Faria and Ana Rita Caldas thank for their grants (TSSiPRO—NORTE‐01‐0145‐ FEDER‐000015—supported by the regional operational program NORTE 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund)por
dc.language.isoengpor
dc.publisherElsevierpor
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FFIS%2F04650%2F2019/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04469%2F2020/PTpor
dc.relationPTDC/NAN-MAT/326512017por
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00526%2F2018%2FCP1581%2FCT0021/PTpor
dc.rightsrestrictedAccesspor
dc.subjectChemical UV filterspor
dc.subjectPhysical UV filterspor
dc.subjectLipid nanocarrierspor
dc.subjectUV blocking sunscreen gelpor
dc.subjectFunctional textilespor
dc.titleAvobenzone-loaded and omega-3-enriched lipid formulations for production of UV blocking sunscreen gels and textilespor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttps://www.journals.elsevier.com/journal-of-molecular-liquidspor
dc.commentsCEB54542por
oaire.citationIssue116965por
oaire.citationConferencePlaceNetherlands-
oaire.citationVolume342por
dc.date.updated2021-10-09T11:44:30Z-
dc.identifier.doi10.1016/j.molliq.2021.116965por
dc.date.embargo10000-01-01-
dc.subject.fosCiências Naturais::Ciências Biológicaspor
dc.description.publicationversioninfo:eu-repo/semantics/publishedVersion-
dc.subject.wosScience & Technologypor
sdum.journalJournal of Molecular Liquidspor
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