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https://hdl.handle.net/1822/74498
Título: | Towards the reconstruction of the genome-scale metabolic model of Lactobacillus acidophilus La-14 |
Autor(es): | Cunha, Emanuel Zeidan, Ahmad Dias, Oscar |
Palavras-chave: | Genome-scale metabolic model Lactic acid bacteria Probiotic Lactobacillus acidophilus La-14 Metabolic reconstruction |
Data: | 2021 |
Editora: | Springer International Publishing |
Revista: | Advances in Intelligent Systems and Computing |
Citação: | Cunha, Emanuel; Zeidan, Ahmad; Dias, Oscar, Towards the reconstruction of the genome-scale metabolic model of Lactobacillus acidophilus La-14. PACBB 2020 - 14th International Conference Practical Applications of Computational Biology & Bioinformatics. Vol. Advances in Intelligent Systems and Computing 1240, L'Aquila, Italy, Oct 7-9, Springer International Publishing, 205-214, 2021. ISBN: 978-3-030-54568-0 |
Resumo(s): | Lactobacillus acidophilus is a probiotic lactic acid bacterium used in food and dietary supplements for many years. However, despite its importance for industrial development and recognized health-promoting effects, no genome-scale metabolic model has been reported. A GSM model for L. acidophilus La-14 was developed, accounting 494 genes and 783 reactions. A genome annotation was performed to identify the metabolic potential of the bacterium. The biomass composition was determined based on information available in literature and previously published models. The model was validated by comparing in silico simulations with experimental data, regarding the aerobic and anaerobic growth. The reconstruction of the metabolic model has confirmed the fastidious requirements of L. acidophilus for amino acids, fatty acids, and vitamins. This model can be used for a better understanding of the metabolism of this bacterium and identification of industrially desirable compounds. |
Tipo: | Artigo em ata de conferência |
URI: | https://hdl.handle.net/1822/74498 |
ISBN: | 978-3-030-54568-0 |
DOI: | 10.1007/978-3-030-54568-0_21 |
ISSN: | 2194-5357 |
Versão da editora: | https://www.pacbb.net/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Artigos em Livros de Atas / Papers in Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53839_1.pdf | 509,63 kB | Adobe PDF | Ver/Abrir |