Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74761
Título: | The clinical path to deliver encapsulated phages and lysins |
Autor(es): | Pinto, Ana Silva, Maria Daniela Pastrana, Lorenzo M Bañobre-López, Manuel Sillankorva, Sanna |
Palavras-chave: | Bacteriophages Lysins Encapsulation Clinical pathogens Infections Delivery |
Data: | Set-2021 |
Editora: | Oxford University Press |
Revista: | FEMS Microbiology Reviews |
Citação: | Pinto, Ana; Silva, Maria Daniela; Pastrana, Lorenzo M; Bañobre-López, Manuel; Sillankorva, Sanna M., The clinical path to deliver encapsulated phages and lysins. FEMS Microbiology Reviews, 45(5), fuab019, 2021 |
Resumo(s): | The global emergence of multidrug-resistant pathogens is shaping the current dogma regarding the use of antibiotherapy. Many bacteria have evolved to become resistant to conventional antibiotherapy, representing a health and economic burden for those afflicted. The search for alternative and complementary therapeutic approaches has intensified and revived phage therapy. In recent decades, the exogenous use of lysins, encoded in phage genomes, has shown encouraging effectiveness. These two antimicrobial agents reduce bacterial populations; however, many barriers challenge their prompt delivery at the infection site. Encapsulation in delivery vehicles provides targeted therapy with a controlled compound delivery, surpassing chemical, physical and immunological barriers that can inactivate and eliminate them. This review explores phages and lysins' current use to resolve bacterial infections in the respiratory, digestive, and integumentary systems. We also highlight the different challenges they face in each of the three systems and discuss the advances towards a more expansive use of delivery vehicles. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/74761 |
DOI: | 10.1093/femsre/fuab019 |
ISSN: | 0168-6445 |
Versão da editora: | https://academic.oup.com/femsre/article-abstract/45/5/fuab019/6204673 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_54385_1.pdf Acesso restrito! | 10,37 MB | Adobe PDF | Ver/Abrir |