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TitleFishroesomes as carriers with antioxidant and anti-inflammatory bioactivities
Author(s)Guedes, Marta
Vieira, Sara Filipa Fontoura
Reis, R. L.
Ferreira, Helena Susana Costa Machado
Neves, N. M.
KeywordsAnti-inflammatory activity
Antioxidant activity
Inflammatory diseases
Sardine roe
Issue dateApr-2021
JournalBiomedicine & Pharmacotherapy
CitationGuedes M., Vieira S. F., Reis R. L., Ferreira H., Neves N. M. Fishroesomes as carriers with antioxidant and anti-inflammatory bioactivities, Biomedicine & Pharmacotherapy, Vol. 140, pp. 111680, doi:10.1016/j.biopha.2021.111680, 2021
Abstract(s)The great diversity of marine habitats and organisms renders them a high-value source to find/develop novel drugs and formulations. Therefore, herein, sardine (Sardina pilchardus) roe was used as a lipidic source to produce liposomes. This fish product presents high nutritional value, being its lipidic content associated with important health benefits. Consequently, it can be advantageously used to produce therapeutically active delivery devices. Roe lipids were extracted using the Matyash method. After lipid film hydration and extrusion, sardine roe-derived large unilamellar liposomes (LUVs), designated as fishroesomes, presented a size of â 330 nm and a significant negative surface charge (â - 27 mV). Radical scavenging assays demonstrated that fishroesomes efficiently neutralized peroxyl, hydroxyl and nitric oxide radicals. Moreover, fishroesomes significantly reduced the expression of pro-inflammatory cytokines and chemokines by LPS-stimulated macrophages at non-toxic concentrations for L929 and THP-1 cells. Consequently, the developed liposomes exhibit unique properties as bioactive drug carriers for inflammatory diseases treatment.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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