Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75268
Título: | Biomimetic and cell-based nanocarriers – New strategies for brain tumor targeting |
Autor(es): | Mendanha, D. Castro, Joana Isabel Martins Cosme Vieira Ferreira, Helena Susana Costa Machado Neves, N. M. |
Palavras-chave: | Biomimetic carriers Blood-brain barrier Cell membrane Drug delivery Glioblastoma |
Data: | Set-2021 |
Editora: | Elsevier |
Revista: | Journal of Controlled Release |
Citação: | Mendanha D., Vieira de Castro J., Ferreira H., Neves N. M. Biomimetic and cell-based nanocarriers - New strategies for brain tumor targeting, Journal of Controlled Release, Vol. 337, pp. 482-493, doi:10.1016/j.jconrel.2021.07.047, 2021 |
Resumo(s): | In the last two decades no significant advances were achieved in the treatment of the most frequent and malignant types of brain tumors. The main difficulties in achieving progress are related to the incapacity to deliver drugs in therapeutic amounts into the central nervous system and the associated severe side effects. Indeed, to obtain effective treatments, the drugs should be able to cross the intended biological barriers and not being inactivated before reaching the specific therapeutic target. To overcome these challenges the development of synthetic nanocarriers has been widely explored for brain tumor treatment but unfortunately with no clinical translation until date. The use of cell-derived nanocarriers or biomimetic nanocarriers has been studied in the last few years, considering their innate bio-interfacing properties. The ability to carry therapeutic agents and a higher selectivity towards brain tumors would bring new hope for the development of safe and effective treatments. In this review, we explore the biological barriers that need to be crossed for effective delivery in brain tumors, and the types and properties of cell-based nanocarriers (extracellular vesicles and cell-membrane coated nanocarriers) currently under investigation. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/75268 |
DOI: | 10.1016/j.jconrel.2021.07.047 |
ISSN: | 0168-3659 |
e-ISSN: | 1873-4995 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0168365921003989 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20679-manuscript-biomimetic-and-cell-based-nanocarriers-new-strategies-brain-tumor-targeting.pdf Acesso restrito! | 3,23 MB | Adobe PDF | Ver/Abrir |