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https://hdl.handle.net/1822/75624
Título: | Hydroxypropyl methylcellulose-based micro- and nanostructures for encapsulation of melanoidins: Effect of electrohydrodynamic processing variables on morphological and physicochemical properties |
Autor(es): | Silva, Pedro Miguel Peixoto Prieto, C. Andrade, C. C. P. Lagarón, J. M. Pastrana, L. M. Coimbra, M. A. Vicente, A. A. Cerqueira, Miguel Ângelo Parente Ribeiro |
Palavras-chave: | Nanofibers Microparticles Encapsulation Electrospinning Electrospray |
Data: | 31-Mar-2022 |
Editora: | Elsevier |
Revista: | International Journal of Biological Macromolecules |
Citação: | Silva, Pedro; Prieto, C.; Andrade, C. C. P.; Lagarón, J. M.; Pastrana, L. M.; Coimbra, M. A.; Vicente, António A.; Cerqueira, Miguel A., Hydroxypropyl methylcellulose-based micro- and nanostructures for encapsulation of melanoidins: Effect of electrohydrodynamic processing variables on morphological and physicochemical properties. International Journal of Biological Macromolecules, 202, 453-467, 2022 |
Resumo(s): | Electrohydrodynamic processing (EHDP) allows the use of a wide range of biopolymers and solvents, including food-grade biopolymers and green solvents, for the development of micro- and nanostructures. These structures present a high surface-area-to-volume ratio and different shapes and morphologies. The aim of this work was to design and produce hydroxypropyl methylcellulose (HPMC)-based micro- and nanostructures through EHD processing using green solvents, while exploring the influence of process and solution parameters, and incorporating a bioactive extracted from a food by-product. Low (LMW) and high (HMW) molecular weight HPMC have been used as polymers. The design-of-experiments methodology was used to determine the effects of process parameters (polymer concentration, flow rate, tip-to-collector distance, and voltage) of EHDP on the particle and fibre diameter, aspect ratio, diameter distribution, aspect ratio distribution, and percentage of fibre breakage. Additionally, melanoidins extracted from spent coffee grounds were encapsulated into the HPCM-based structures at a concentration of 2.5mg melanoidins/mL of the polymer solution. Polymer solutions were characterised regarding their viscosity, surface tension and conductivity, and showed that the incorporation of melanoidins increased the viscosity and conductivity values of the polymer solutions. The developed structures were characterised regarding their thermal, crystallinity and morphological properties before and after melanoidin incorporation and it was observed that melanoidin incorporation did not significantly influence the characteristics of the produced micro- and nanostructures. Based on the results, it is possible to envision the use of the produced micro- and nanostructures in a wide range of applications, both in food and biomedical fields. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/75624 |
DOI: | 10.1016/j.ijbiomac.2022.01.019 |
ISSN: | 0141-8130 |
Versão da editora: | http://www.elsevier.com/locate/issn/01418130 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55186_1.pdf Acesso restrito! | 2,94 MB | Adobe PDF | Ver/Abrir |