Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/77636

TítuloPreclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebellar ataxia type 3
Autor(es)Correia, Joana Sofia Silva
Carvalho, Andreia Alexandra Neves
Pinheiro, Bárbara Filipa Mendes
Pires, Joel Pereira
Teixeira, Fábio Gabriel Rodrigues
Lima, Rui Augusto Ribeiro
Monteiro, Susana Isabel Gonçalves
Silva, Nuno André Martins
Cunha, Carina Isabel Soares
Serra, Sofia Cravino
Silva, Sara Carina Duarte
Castro, Andreia Cristiana Teixeira
Salgado, A. J.
Maciel, P.
Palavras-chaveHuman mesenchymal stem cells
Secretome
Neurodegeneration
Spinocerebellar ataxia type 3
Preclinical trial
Data24-Nov-2021
EditoraMultidisciplinary Digital Publishing Institute (MDPI)
RevistaBiomedicines
CitaçãoCorreia, J.S.; Neves-Carvalho, A.; Mendes-Pinheiro, B.; Pires, J.; Teixeira, F.G.; Lima, R.; Monteiro, S.; Silva, N.A.; Soares-Cunha, C.; Serra, S.C.; Duarte-Silva, S.; Teixeira-Castro, A.; Salgado, A.J.; Maciel, P. Preclinical Assessment of Mesenchymal-Stem-Cell-Based Therapies in Spinocerebellar Ataxia Type 3. Biomedicines 2021, 9, 1754. https://doi.org/10.3390/biomedicines9121754
Resumo(s)The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for neurodegenerative diseases, including spinocerebellar ataxias. Spinocerebellar ataxia type 3 (SCA3)—or Machado–Joseph disease (MJD)—is the most common dominant ataxia, being mainly characterized by motor deficits; however, SCA3/MJD has a complex and heterogeneous pathophysiology, involving many CNS brain regions, contributing to the lack of effective therapies. Mesenchymal stem cells (MSCs) have been proposed as a potential therapeutic tool for CNS disorders. Beyond their differentiation potential, MSCs secrete a broad range of neuroregulatory factors that can promote relevant neuroprotective and immunomodulatory actions in different pathophysiological contexts. The objective of this work was to study the effects of (1) human MSC transplantation and (2) human MSC secretome (CM) administration on disease progression in vivo, using the CMVMJD135 mouse model of SCA3/MJD. Our results showed that a single CM administration was more beneficial than MSC transplantation—particularly in the cerebellum and basal ganglia—while no motor improvement was observed when these cell-based therapeutic approaches were applied in the spinal cord. However, the effects observed were mild and transient, suggesting that continuous or repeated administration would be needed, which should be further tested.
TipoArtigo
URIhttps://hdl.handle.net/1822/77636
DOI10.3390/biomedicines9121754
e-ISSN2227-9059
Versão da editorahttps://www.mdpi.com/2227-9059/9/12/1754
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:BUM - MDPI

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
biomedicines-09-01754.pdf3,03 MBAdobe PDFVer/Abrir

Este trabalho está licenciado sob uma Licença Creative Commons Creative Commons

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID