Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/77636
Título: | Preclinical assessment of mesenchymal-stem-cell-based therapies in spinocerebellar ataxia type 3 |
Autor(es): | Correia, Joana Sofia Silva Carvalho, Andreia Alexandra Neves Pinheiro, Bárbara Filipa Mendes Pires, Joel Pereira Teixeira, Fábio Gabriel Rodrigues Lima, Rui Augusto Ribeiro Monteiro, Susana Isabel Gonçalves Silva, Nuno André Martins Cunha, Carina Isabel Soares Serra, Sofia Cravino Silva, Sara Carina Duarte Castro, Andreia Cristiana Teixeira Salgado, A. J. Maciel, P. |
Palavras-chave: | Human mesenchymal stem cells Secretome Neurodegeneration Spinocerebellar ataxia type 3 Preclinical trial |
Data: | 24-Nov-2021 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Biomedicines |
Citação: | Correia, J.S.; Neves-Carvalho, A.; Mendes-Pinheiro, B.; Pires, J.; Teixeira, F.G.; Lima, R.; Monteiro, S.; Silva, N.A.; Soares-Cunha, C.; Serra, S.C.; Duarte-Silva, S.; Teixeira-Castro, A.; Salgado, A.J.; Maciel, P. Preclinical Assessment of Mesenchymal-Stem-Cell-Based Therapies in Spinocerebellar Ataxia Type 3. Biomedicines 2021, 9, 1754. https://doi.org/10.3390/biomedicines9121754 |
Resumo(s): | The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies for neurodegenerative diseases, including spinocerebellar ataxias. Spinocerebellar ataxia type 3 (SCA3)—or Machado–Joseph disease (MJD)—is the most common dominant ataxia, being mainly characterized by motor deficits; however, SCA3/MJD has a complex and heterogeneous pathophysiology, involving many CNS brain regions, contributing to the lack of effective therapies. Mesenchymal stem cells (MSCs) have been proposed as a potential therapeutic tool for CNS disorders. Beyond their differentiation potential, MSCs secrete a broad range of neuroregulatory factors that can promote relevant neuroprotective and immunomodulatory actions in different pathophysiological contexts. The objective of this work was to study the effects of (1) human MSC transplantation and (2) human MSC secretome (CM) administration on disease progression in vivo, using the CMVMJD135 mouse model of SCA3/MJD. Our results showed that a single CM administration was more beneficial than MSC transplantation—particularly in the cerebellum and basal ganglia—while no motor improvement was observed when these cell-based therapeutic approaches were applied in the spinal cord. However, the effects observed were mild and transient, suggesting that continuous or repeated administration would be needed, which should be further tested. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/77636 |
DOI: | 10.3390/biomedicines9121754 |
e-ISSN: | 2227-9059 |
Versão da editora: | https://www.mdpi.com/2227-9059/9/12/1754 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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biomedicines-09-01754.pdf | 3,03 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons