Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/78311
Título: | Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
Autor(es): | Veloso, Sergio R. S. Tiryaki, Ecem Spuch, Carlos Hilliou, L. Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueirino, Veronica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
Data: | Mar-2022 |
Editora: | Royal Society of Chemistry |
Revista: | Nanoscale |
Citação: | Veloso, S. R. S., Tiryaki, E., Spuch, C., Hilliou, L., Amorim, C. O., Amaral, V. S., … Castanheira, E. M. S. (2022). Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels. Nanoscale. Royal Society of Chemistry (RSC). http://doi.org/10.1039/d1nr08158f |
Resumo(s): | Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/78311 |
DOI: | 10.1039/d1nr08158f |
ISSN: | 2040-3364 |
Versão da editora: | https://pubs.rsc.org/en/content/articlelanding/2022/NR/D1NR08158F |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Manuscript_clean.pdf | 2,07 MB | Adobe PDF | Ver/Abrir | |
Supplementary Information.pdf | 18,48 MB | Adobe PDF | Ver/Abrir |