Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/78453
Título: | Metronidazole delivery nanosystem able to reduce the pathogenicity of bacteria in colorectal infection |
Autor(es): | Oliveira, Ana Araújo, Ana Rodrigues, Luísa C. Silva, Catarina S. Reis, R. L. Neves, N. M. Leão, Pedro Martins, Albino |
Palavras-chave: | Antibacterial Colorectal Electrospun fibrous meshes Metronidazole Nanoparticles |
Data: | Mai-2022 |
Editora: | ACS Publications |
Revista: | Biomacromolecules |
Citação: | Oliveira A., Araujo A., Rodrigues L.C., Silva C. S., Reis R. L., Neves N. M., Leão P., Martins A. Metronidazole Delivery Nanosystem Able To Reduce the Pathogenicity of Bacteria in Colorectal Infection, Biomacromolecules, Vol. 23, Issue 6, pp. 2415-2427, doi:10.1021/acs.biomac.2c00186, 2022 |
Resumo(s): | Metronidazole (MTZ) is a drug potentially used for the treatment of intestinal infections, namely, the ones caused by colorectal surgery. The traditional routes of administration decrease its local effectiveness and present off-site effects. To circumvent such limitations, herein a drug delivery system (DDS) based on MTZ-loaded nanoparticles (NPs) immobilized at the surface of electrospun fibrous meshes is proposed. MTZ at different concentrations (1, 2, 5, and 10 mg mLâ 1) was loaded into chitosanâ sodium tripolyphosphate NPs. The MTZ loaded into NPs at the highest concentration showed a quick release in the first 12 h, followed by a gradual release. This DDS was not toxic to human colonic cells. When tested against different bacterial strains, a significant reduction of Escherichia coli and Staphylococcus aureus was observed, but no effect was found against Enterococcus faecalis. Therefore, this DDS offers high potential to locally prevent the occurrence of infections after colorectal anastomosis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/78453 |
DOI: | 10.1021/acs.biomac.2c00186 |
ISSN: | 2415-2427 |
Versão da editora: | https://doi.org/10.1021/acs.biomac.2c00186 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20782-acsbiomac2c00186.pdf Acesso restrito! | 731,42 kB | Adobe PDF | Ver/Abrir |