Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/79385
Título: | Colistin conditioning surfaces combined with antimicrobial treatment to prevent ventilator-associated infections |
Autor(es): | Alves, Diana Filipa Barros Lopes, Hélder Machado, Idalina Pereira, Maria Olívia |
Palavras-chave: | Ventilator-associated pneumonia Biofilms Pseudomonas aeruginosa Colistin |
Data: | 28-Jul-2022 |
Editora: | Taylor & Francis |
Revista: | Biofouling |
Citação: | Alves, Diana; Lopes, Hélder; Machado, I.; Pereira, Maria Olívia, Colistin conditioning surfaces combined with antimicrobial treatment to prevent ventilator-associated infections. Biofouling, 38(6), 547-557, 2022 |
Resumo(s): | Biofilm formation on endotracheal tubes (ETT) is an important factor in the development of ventilator-associated pneumonia (VAP). This work aimed to investigate the effectiveness of colistin (COL) against the early stages of biofilm formation by Pseudomonas aeruginosa. Two strategies were used: pre-conditioning the adhesion surfaces with COL before biofilm formation and growing biofilms in its presence. The combined effect of treating P. aeruginosa 24-hours old biofilms with Ciprofloxacin (CIP) or colistin (COL) on clean and COL-conditioned surfaces was also assessed. Random deposition of COL residues altered the physico-chemical properties of the adhesion surfaces and impaired biofilm formation. Moreover, as a consequence of the reduced amount of biofilms attached to COL conditioned surfaces, adhered cells became more exposed to the subsequent action of CIP or COL, suggesting a combined outcome of prophylactic and therapeutic COL-based strategies. Results highlighted the promising use of COL to prevent the establishment of biofilms on ETT. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/79385 |
DOI: | 10.1080/08927014.2022.2088284 |
ISSN: | 0892-7014 |
e-ISSN: | 1029-2454 |
Versão da editora: | http://www.tandfonline.com/action/journalInformation?journalCode=gbif20 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55662_1.pdf Acesso restrito! | 1,62 MB | Adobe PDF | Ver/Abrir |