Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/79807

TitleIn vitro cancer models: a closer look at limitations on translation
Author(s)Antunes, Nina
Kundu, Banani
Kundu, Subhas C
Reis, R. L.
Correlo, V. M.
Keywordscancer
3D cancer models
point-of-care modelling tool
gap analysis
commercialization
Issue date7-Apr-2022
PublisherMultidisciplinary Digital Publishing Institute
JournalBioengineering
CitationAntunes, N.; Kundu, B.; Kundu, S.C.; Reis, R.L.; Correlo, V. In Vitro Cancer Models: A Closer Look at Limitations on Translation. Bioengineering 2022, 9, 166. https://doi.org/10.3390/bioengineering9040166
Abstract(s)In vitro cancer models are envisioned as high-throughput screening platforms for potential new therapeutic discovery and/or validation. They also serve as tools to achieve personalized treatment strategies or real-time monitoring of disease propagation, providing effective treatments to patients. To battle the fatality of metastatic cancers, the development and commercialization of predictive and robust preclinical in vitro cancer models are of urgent need. In the past decades, the translation of cancer research from 2D to 3D platforms and the development of diverse in vitro cancer models have been well elaborated in an enormous number of reviews. However, the meagre clinical success rate of cancer therapeutics urges the critical introspection of currently available preclinical platforms, including patents, to hasten the development of precision medicine and commercialization of in vitro cancer models. Hence, the present article critically reflects the difficulty of translating cancer therapeutics from discovery to adoption and commercialization in the light of in vitro cancer models as predictive tools. The state of the art of in vitro cancer models is discussed first, followed by identifying the limitations of bench-to-bedside transition. This review tries to establish compatibility between the current findings and obstacles and indicates future directions to accelerate the market penetration, considering the niche market.
TypeArticle
URIhttps://hdl.handle.net/1822/79807
DOI10.3390/bioengineering9040166
e-ISSN2306-5354
Publisher versionhttps://www.mdpi.com/2306-5354/9/4/166
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
bioengineering-09-00166-v2.pdf1,3 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID