Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/80276

TitleCurrent challenges for biological treatment of pharmaceutical-based contaminants with oxidoreductase enzymes: immobilization processes, real aqueous matrices and hybrid techniques
Author(s)Sá, Helena Isabel Oliveira
Michelin, Michele
Tavares, T.
Silva, Bruna Andreia Nogueira Airosa
KeywordsOxidoreductases
Pharmaceuticals
Enzyme immobilization
Biodegradation
Wastewater
Hybrid techniques
Issue date15-Oct-2022
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
JournalBiomolecules
CitationSá, Helena; Michelin, Michele; Tavares, Teresa; Silva, Bruna, Current challenges for biological treatment of pharmaceutical-based contaminants with oxidoreductase enzymes: immobilization processes, real aqueous matrices and hybrid techniques. Biomolecules, 12(10), 1489, 2022
Abstract(s)The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive deterioration of water quality with adverse impacts on the ecosystem and human health. To address this challenge, there is currently an evolving trend toward the search for effective methods to ensure efficient purification of both drinking water and wastewater. Biocatalytic transformation of pharmaceuticals using oxidoreductase enzymes, such as peroxidase and laccase, is a promising environmentally friendly solution for water treatment, where fungal species have been used as preferred producers due to their ligninolytic enzymatic systems. Enzyme-catalyzed degradation can transform micropollutants into more bioavailable or even innocuous products. Enzyme immobilization on a carrier generally increases its stability and catalytic performance, allowing its reuse, being a promising approach to ensure applicability to an industrial scale process. Moreover, coupling biocatalytic processes to other treatment technologies have been revealed to be an effective approach to achieve the complete removal of pharmaceuticals. This review updates the state-of-the-art of the application of oxidoreductases enzymes, namely laccase, to degrade pharmaceuticals from spiked water and real wastewater. Moreover, the advances concerning the techniques used for enzyme immobilization, the operation in bioreactors, the use of redox mediators, the application of hybrid techniques, as well as the discussion of transformation mechanisms and ending toxicity, are addressed.
TypeArticle
URIhttps://hdl.handle.net/1822/80276
DOI10.3390/biom12101489
e-ISSN2218-273X
Publisher versionhttps://www.mdpi.com/journal/biomolecules
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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