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TitleCandida auris, a singular emergent pathogenic yeast: its resistance and new therapeutic alternatives
Author(s)Fernandes, Liliana Sousa
Ribeiro, Rita
Henriques, Mariana
Rodrigues, Maria Elisa
KeywordsCandida auris
Antifungal resistance
New treatments
Issue date6-Oct-2022
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
CitationFernandes, L., Ribeiro, R., Henriques, M. et al. Candida auris, a singular emergent pathogenic yeast: its resistance and new therapeutic alternatives. Eur J Clin Microbiol Infect Dis 41, 1371–1385 (2022).
Abstract(s)Nowadays, fungal infections affect millions of people across the world. Candida auris, a new emergent yeast, is a worrisome pathogen because it associates with a high rate of incidence and prevalence, including in the nosocomial environment. The hard identification, the phenotypic plasticity, and the easy adaptation to stressful conditions are some of the C. auris traits that render this latest yeast singular challenging. C. auris infections have already been reported from more than 30 countries and are associated with high mortality rates. This is the result from rapid transmission and the difficulty of prevention, control, and eradication. There are several factors related to the high virulence of C. auris, such as the multidrug resistance, biofilm development, and the ability to escape the response of the innate immune system. So, C. auris infections are a serious and alarming problem, not only because of the high pathogenicity of the fungal agent but also because of the low effectiveness of the treatments available. Although new formulations have been developed against C. auris strains, a better understanding is essential to efficiently treat, prevent, and control C. auris infections.
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AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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