Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80976
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Melro, Liliana | por |
dc.contributor.author | Tavares, Tânia D. | por |
dc.contributor.author | Padrão, Jorge | por |
dc.contributor.author | Dourado, Fernando | por |
dc.contributor.author | Gama, F. M. | por |
dc.contributor.author | Silva, C. | por |
dc.contributor.author | Antunes, Joana C. | por |
dc.contributor.author | Felgueiras, Helena Prado | por |
dc.contributor.author | Zille, Andrea | por |
dc.date.accessioned | 2022-12-06T11:29:49Z | - |
dc.date.available | 2022-12-06T11:29:49Z | - |
dc.date.issued | 2022-06-15 | - |
dc.identifier.citation | Melro, Liliana; Tavares, Tânia D.; Padrão, Jorge; Dourado, Fernando; Gama, F. M.; Silva, Carla; Antunes, Joana C.; Felgueiras, Helena P.; Zille, Andrea, Antimicrobial activity of a bacterial nanocellulose film functionalized with nisin Z for prospective burn wounds treatment. Medical Sciences Forum. Vol. 12(1), MDPI AG, 1, 2022. | por |
dc.identifier.issn | 2673-9992 | por |
dc.identifier.uri | https://hdl.handle.net/1822/80976 | - |
dc.description | Supplementary Materials: The following are available online at https://www.mdpi.com/article/10 .3390/eca2022-12708/s1 | por |
dc.description.abstract | Burn wounds can lead to numerous severe complications including bacterial infections causing patient morbidity and mortality, mostly in low- and middle-income countries. The considerable increase in microbial resistance against traditional antibiotics is leading towards alternative strategies to treat bacterial infections. Nisin Z is an antimicrobial peptide which exhibits a significant antibacterial activity against Gram-positive bacteria. Its efficacy against Gram-negative bacteria is limited, nonetheless it can be improved with the addition of surfactants, such as ethylenediaminetetraacetic acid (EDTA). The incorporation of peptide and other biomolecules within a biopolymer matrix provides protection maintaining their antimicrobial potential. Bacterial nanocellulose (BNC) has been widely used as wound dressings. Its impressive water retention capacity (>99%) and porosity are beneficial to manage wounds due to its potential to absorb exudates, providing a breathable and humid environment. In this work, the functionalization of BNC with Nisin Z (BNC-NZ) via vacuum filtration is reported. The entrapment of the peptide inside the BNC films was confirmed through morphological characterization using attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectrometry. Typical absorbance peaks of Nisin Z are easily identifiable at 1647 cm−1 (amide group) and 1520 cm−1 (bending of primary amines). Thermal gravimetric analysis (TGA) suggested that Nisin Z did not interfere with the BNC matrix. The antimicrobial activity of Nisin Z against five of the most common bacteria found in burn wounds was verified by minimum bactericidal concentration (MBC) ranging 8.0–256.0 µg/mL. Agar diffusion and shake flask methods revealed the potential of BNC-NZ for prospective applications in burn wound dressings. | por |
dc.description.sponsorship | This research was funded by FEDER funds through COMPETE and by national funds through FCT via the projects POCI-01-0145-FEDER-028074 and UID/CTM/00264/2020. L.M. and T.D.T. also acknowledge FCT for their Ph.D. scholarships with references 2020.04919.BD and 2020.06046.BD. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00264%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/2020.04919.BD/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/2020.06046.BD/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | antimicrobial peptides | por |
dc.subject | Nisin Z | por |
dc.subject | bacterial nanocellulose | por |
dc.subject | wound dressing | por |
dc.title | Antimicrobial activity of a bacterial nanocellulose film functionalized with nisin Z for prospective burn wounds treatment | por |
dc.type | conferenceAbstract | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2673-9992/12/1/1 | por |
dc.comments | CEB55928 | por |
oaire.citationStartPage | 1 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2022-12-05T23:24:52Z | - |
dc.identifier.doi | 10.3390/eca2022-12708 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.journal | Medical Sciences Forum | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series DET/2C2T - Comunicações em congressos internacionais com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55928_1.pdf | 216,23 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons